The hyponatremia intervention trial is finally published. The Filtrate explores the details
The Filtrate
Joel Topf kidneyboy.bsky.social
Swapnil Hiremath @hswapnil.medsky.social
Pedro Teixeira @nephcrit.bsky.social
Special Guests
Ewout J. Hoorn, Professor of Medicine Erasmus MC, Netherlands. One of the primary authors.
Harish Seethapathy, Assistant physician at Massachusetts General Hospital
Editing
Vipin Verghese
The Kidney Connection written and performed by Timothy Yau
Show Notes
A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients in NEJM Evidence, in PubMed, in NephJC
Seethapathy: Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis in NEJM Evidence
MacMillan: Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia in NEJM Evidence
SALSA: Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia: The SALSA Randomized Clinical Trial in JAMA Internal Medicine
SALT 1 and 2: Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia in NEJM
Hyponatremia registry: Current treatment practice and outcomes. Report of the hyponatremia registry in Kidney International
The Richard Sterns’ article on the lower mortality with more severe hyponatremia: Mortality and Serum Sodium: Do Patients Die from or with Hyponatremia? in CJASN
The European Hyponatremia Guidelines: Clinical practice guideline on diagnosis and treatment of hyponatraemia in The European Journal of Endocrinology
The American Hyponatremia Guidelines: Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations in American Journal of Medicine
Treating hyponatremia: damned if we do and damned if we don't by Tom Berl in Kidney International
Prospective (clamp) versus reactive (rescue) DDAVP in hyponatremia: Safety and efficacy of proactive versus reactive administration of desmopressin in severe symptomatic hyponatremia: a randomized controlled trial in Nature Scientific Reports and as covered in PBFluids
Helbert Rondon’s RCT of urea Urea for Chronic Hyponatremia on ClinicalTrials.gov
Tubular Secretions
Swapnil: Catfishing on CatNet: A Novel by Naomi Kritzer (Amazon)
Harish: Disney Cruise
Edward: Flesh: A Novel (Booker Prize Winner) by David Szalay (Amazon)
Pedro: Scrubs reboot (IMDB)
Joel: KIDNEYcon