We bring some of the biggest names in Kidney Stone Nephrology to defend their field from another negative RCT
The Filtrate
Joel Topf @kidney_boy
Vipin Verghese @vipvargh.bsky.social
Nayan Arora @captainchloride
Special Guests
David Goldfarb Professor of Medicene, NYU (COI)
Megan Prochaska Assistant professor of medicine at University of Chicago
John Asplin Medical Director Consultant LithoLink (Twitter)
Editing
Anna Gaddy
The Kidney Connection written and performed by Timothy Yau
Show Notes
Kidney Treks, University of Chicago. For medical students.
The Push Trial: Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention NephJC Short | The Lancet
Charlie Pak trial showing increased urine volume reduced risk of kidney stones. Evidence justifying a high fluid intake in treatment of nephrolithiasis PubMed
The Borghi Trial: Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study PubMed
Medical Management of Kidney Stones: AUA Guideline (2026)
Weird little trial Asplin mentioned with amlodipine. But it was actually verapami. By Kemal Sarical: The effect of calcium channel blockers on stone regrowth and recurrence after shock wave lithotripsy PubMed
Borghi’s other giant study in kidney stones: Comparison of Two Diets for the Prevention of Recurrent Stones in Idiopathic Hypercalciuria NEJM
The No Stone Trial: Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence NephJC | NEJM
Gary Curhan epidemiologic data from the Nurses Health Study and the Health Professionals Follow-up Study: Twenty-four-hour urine chemistries and the risk of kidney stones among women and men PubMed
Gary Curhan epidemiologic data on sugar sweetened beverages and risk of kidney stones. Soda and other beverages and the risk of kidney stones PubMed
Eric Topol’s tweet:
NephJC in 2014 on the ACP Kidney Stone Guidelines NephJC
Goldfarb’s scathing editorial on said guidelines, not on NephJC as I said but, on Fred Coe’s website at the University of Chicago. Link
Tubular Secretions
Nayan: Shrinking on Apple TV Wikipedia
David: The deaths of Sonny Rollins (Wikipedia) and James Blood Ulmer (Wikipedia)
Megan: Sri Lanka for travel (National Geographic)
Vipin: Memory Eternal: Living with Grief as Orthodox Christians (Amazon)
John: A History of Rock Music in 500 Songs (Link) Patty Smith’s memoir, Just Kids (Amazon)
Joel: This is How You Lose The War by Amal El-Mohtar and Max Gladstone (Amazon) for the second time, and Acquired PodCast (Link)