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NephJC

Queue
Flozinator
Blog
Podcasts
Freely Filtered
RoboPod
Channel Your Enthusiasm
More
Club de Articulos
Code of Conduct
The Why, When and How
The NephJC Organization
Twitter Journal Club Primer
Who are we
Masthead
COVID19
Seminars in Nephrology
Regarding Twitter...
Newsletter
September 15, 2025
Background, summary
Brian Rifkin
PREVENT, Detect, Treat: What’s New in the 2025 ...

This week, we will discuss the AHA/ACC 2025 hypertension guideline update. Wow, have eight years flown by?

PREVENT, Detect, Treat: What’s New in the 2025 Hypertension Toolkit
September 1, 2025
Background
swapnil hiremath
In ESRD is spironolactone an overACHIEVEr?

This week, we will discuss the ACHIEVE trial. Will spironolactone achieve CV benefits in ESRD?

In ESRD is spironolactone an overACHIEVEr?
August 18, 2025
Background
joel topf
#NephJC Summer Bookclub: Everything is ...

The summer book club started in 2015, with one of the best books we have done in book club, Atul Gawande's Being Mortal. I think it should be required reading for all physicians. So now, in 2025, it is the NephJC Summer Book’s tenth anniversary (which represents our eleventh book). The history has been rich:

#NephJC Summer Bookclub: Everything is Tuberculosis by John Green
August 4, 2025
Background
Cristina Adriana Popa
High or Low Phosphate? Are we Missing the ...

This week, we will discuss the phosphate targets in dialysis. Are you aiming for HIgh or Low?

High or Low Phosphate?  Are we Missing the (P)oint?
July 21, 2025
Background
Brian Rifkin
Mind The Gap: When eGFR Creatinine and Cystatin ...

This week, we will discuss the clinical significance of eGFRdiff, the difference in eGFRcys (cystatin C) and eGFRcr (creatinine).

Mind The Gap: When eGFR Creatinine and Cystatin C Disagree
swapnil hiremath
April 14, 2020
Background

COVID in the Kidney: An Autopsy Series

swapnil hiremath
April 14, 2020
Background
COVID in the Kidney: An Autopsy Series

This week, as an emergency chat, we will discuss some hot-off-the-press data. Published a few days ago, the first look at what happens in the kidneys.

Tagged: tiff caza, kidney international, biopsy, pathology, covidaki, covidautopsy, covid-19

swapnil hiremath
April 7, 2020
Commentary

MinTac: The Visual Abstract

swapnil hiremath
April 7, 2020
Commentary

The trial is from cJASN, so we do have a visual abstract from Pablo Garcia, in the cJASN style

And Omar as well created another visual abstract, in his own inimitable style

Tagged: visual abstract, mintac, Visual Abstract, cjasn, Garcia, Omar

swapnil hiremath
April 6, 2020
Background

Minimal Role for Steroids in Minimal Change Disease?

swapnil hiremath
April 6, 2020
Background
Minimal Role for Steroids in Minimal Change Disease?

Steroids are the mainstay of minimal change. Or are they? Lets explore an RCT that bravely challenges the status quo of steroids with tacrolimus monotherapy

Tagged: glomerulonephritis, trial, RCT, mcd, minimal change, tacrolimus, renua, jasn, mintac

swapnil hiremath
March 28, 2020
news, Commentary

TRANSPLANT

swapnil hiremath
March 28, 2020
news, Commentary
TRANSPLANT

This page discusses the common questions transplant professionals as well as transplant patients may have with COVID-19. We have few facts and little evidence, and those are laid out below. Locally, the decisions being taken depend on local resources, logistics and other factors, and hence local practice may appropriately vary.

Tagged: coronakidney, covid19, Transplant, Beje, Bea, Silvi

swapnil hiremath
March 25, 2020
Commentary, news

PEDIATRICS

swapnil hiremath
March 25, 2020
Commentary, news
PEDIATRICS

COVID-19, the disease caused by SARS-CoV-2, has rapidly become a global pandemic. This review aims to complement the other NephJC pages with a focus on how children with kidney disease are impacted by this pandemic. Our aim is to review what we know about COVID-19 as it pertains to kidney disease in kids.

Tagged: coronakidney, covid19, pediatrics, cathy quinlan, Rheault, Michelle Starr

joel topf
March 24, 2020
news

DIALYSIS and CKD

joel topf
March 24, 2020
news
DIALYSIS and CKD

The NephJC team is working to gather the most up to date and accurate information on how to do chronic dialysis in the middle of the pandemic.

Tagged: coronakidney, covid19, hemodialysis, dialysis

swapnil hiremath
March 21, 2020
Commentary, news

Byrd's Words: Preprints and Peer Review

swapnil hiremath
March 21, 2020
Commentary, news
Byrd's Words: Preprints and Peer Review

What is a preprint anyway? And how is it different from a ‘real’ research paper. What about reviews or perspectives?

Brian Byrd breaks it down for us

Tagged: preprints, Meta, byrd, byrdswords, covid-19

swapnil hiremath
March 21, 2020
Commentary, news

ACUTE KIDNEY INJURY

swapnil hiremath
March 21, 2020
Commentary, news
ACUTE KIDNEY INJURY

As with all the other pages on COVID-19 here on NephJC, this page on AKI & the discussion are not meant to be treatment recommendations based on sound evidence. Our aim on this page is to merely discuss the science of what we know, and some of the biology and mechanisms as well as practical management aspects.

Tagged: covid19, coronakidney, AKI, hiremath, jennie lin, covidaki

swapnil hiremath
March 14, 2020
news

ACE2 and HYPERTENSION

swapnil hiremath
March 14, 2020
news
ACE2 and HYPERTENSION

There has been an unprecedented interest in this topic. Hence we have added more details and moved this section from the main page to a dedicated area with focus on hypertension and ACE2. Curated by Matt Sparks and Swapnil Hiremath, with additional expert input from the COVID-ACE2 workgroup

Tagged: covid19, coronakidney, sars, ace, ace2, hypertension, sparks, hiremath, Hypertension, blood pressure

swapnil hiremath
March 10, 2020
Commentary

ISPD 2020 Recommendations: Dr Liew's Take

swapnil hiremath
March 10, 2020
Commentary
ISPD 2020 Recommendations: Dr Liew's Take

Adrian Liew, one of the principal authors of the new ISPD guidelines on (don’t say adequacy) high-quality goal-directed peritoneal dialysis shares his thoughts on what makes these guidelines unique and ground breaking.

Tagged: ispd, ispd2020, peritoneal dialysis

swapnil hiremath
March 10, 2020
Commentary

ISPD 2020 Recommendations: A Patient Commentary

swapnil hiremath
March 10, 2020
Commentary
ISPD 2020 Recommendations: A Patient Commentary

Steve Quinlan is a patient who did PD for a year. He looked at the 2020 ISPD guidelines of adequacy and he has thoughts…

Tagged: patient voice, Patient Voice, Quinlan, ispd, ispd2020, guidelines, peritoneal dialysis

swapnil hiremath
March 9, 2020
Commentary

ISPD 2020 Recommendations: The Visual Abstract

swapnil hiremath
March 9, 2020
Commentary

It is hard to do a visual abstract for guidelines.

But nothing’s too hard for NSMC graduate and now faculty, Krithika Mohan aka @krithicism

Tagged: ispd, ispd2020, visual abstract, Visual Abstract, krithika

Guest User
March 9, 2020
Background

ISPD Practice Recommendations 2020 - From ‘Patient’ to ‘Person’

Guest User
March 9, 2020
Background
ISPD Practice Recommendations 2020 - From ‘Patient’ to ‘Person’

This week, we will discuss the fresh-off-the-press ISPD recommendations on what they call as ‘prescribing high quality, goal directed’ PD. No mention of adequacy even in the title, in a subtle shade at the move away from numbers to things that really matter.

Tagged: peritoneal dialysis, guidelines, ISPD

joel topf
March 6, 2020
Commentary

Nice PEXIVAS vs MEPEX infographic

joel topf
March 6, 2020
Commentary

Confused about how PEXIVAS reversed MEPEX? Maybe this infographic will help.

Nice work by NSM intern Namrata Parikh.

Infographic PEXIVAS MEPEX 4.0.png

Tagged: pexivas, infographic, mepex

swapnil hiremath
February 24, 2020
Commentary

PEXIVAS: the Visual Abstract

swapnil hiremath
February 24, 2020
Commentary

Beautiful work here from Alex Meraz

PEXIVAS VA.jpg

If you are interested in the NEJM style, here is their own VA:

PEXIVAS VA NEJM.jpg

Tagged: visual abstract, Visual Abstract, pexivas, nejm, alex meraz

swapnil hiremath
February 24, 2020
Background

perPLEXed by ANCA? Let PEXIVAS show you the path to less steroids and the end of plasma exchange

swapnil hiremath
February 24, 2020
Background
perPLEXed by ANCA? Let PEXIVAS show you the path to less steroids and the end of plasma exchange

This week we discuss the long awaited PEXIVAS trial. Reduced dose steroids win, and PLEX loses. Or does it?

Tagged: pexivas, anca, trial, rct, nejm, verner

joel topf
February 11, 2020
Commentary

Visual Abstract on ANCA vasculitis and Myeloperoxidase Inhibition Attenuates Neutrophil Activation

joel topf
February 11, 2020
Commentary

Krithika Mohan came up big this with this week’s visual abstract

Tagged: mpo anca, visual abstract, Visual Abstract

swapnil hiremath
February 11, 2020
Background

Are ANCA actually attackers?

swapnil hiremath
February 11, 2020
Background
Are ANCA actually attackers?

We are now in GN territory this month - or rather ANCA Vasculitis month! First we start off with this paper from London, which uses some data from the RAVE trial along with additional experiments to show some intriguing results on the role of MPO.

Tagged: mpo anca, jasn, basic science, basic, mouse, tiff caza

Matt Sparks
February 6, 2020
news

Announcing the NSMC Internship Class of 2020

Matt Sparks
February 6, 2020
news
Announcing the NSMC Internship Class of 2020

The 6th class of NSMC interns is ready to go. Meet the new interns and then go follow them on Twitter so you don’t miss their excellent content.

Tagged: NSMC

swapnil hiremath
January 28, 2020
Commentary

GAD is still BAD: A Commentary

swapnil hiremath
January 28, 2020
Commentary
GAD is still BAD: A Commentary

A commentary from Prof Wagner, making the case that gadolinium remains toxic and we should remain wary of using it indiscriminately

Tagged: commentary, brent wagner, gadsnotbad, gadolinium

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