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NephJC

Queue
Flozinator
Blog
PodCast
More
Club de Articulos
Code of Conduct
The Why, When and How
The NephJC Organization
Twitter Journal Club Primer
Who are we
Masthead
COVID19
Seminars in Nephrology
Regarding Twitter...
Newsletter
April 28, 2025
Background
Cristina Adriana Popa
Kidney Allografts-Play With Fire, Get Burned

This week, we will discuss the prognostic role of microvascular inflammation in kidney transplantation. Can the capillaries whisper their damage in lesions before antibodies speak? Maybe this study compels us to treat the injury we see, not just the disease we can name…

Kidney Allografts-Play With Fire, Get Burned
April 14, 2025
Background
swapnil hiremath
Metformin- Should I Stay or Should I Go

This week, we will discuss another target trial emulation study. The FDA says to stop metformin at a GFR of 30. Are they right?

Metformin- Should I Stay or Should I Go
March 23, 2025
Background
Brian Rifkin
KDIGO 2025 ADPKD Guidelines Review

This week, we will discuss the first iteration of KDIGO’s 2025 guidelines on ADPKD.  These guidelines are a result of a decade of global collaboration between physicians, researchers, advocates, and patients. The guidelines incorporate ADPKD-specific care as well as many general CKD management practice points.


KDIGO 2025 ADPKD Guidelines Review
March 11, 2025
Background
Cristina Adriana Popa
REGENCY: A B-Cell Super Destroyer in Lupus

This week, we will celebrate in advance World Kidney Day by discussing the results of OBInutuzumab in active lupus nephritis. The LUNAR trial (rituximab versus placebo) was “almost” positive, but not quite there. Would Obi overpower its cousin ritux? ✨

REGENCY: A B-Cell Super Destroyer in Lupus
February 24, 2025
Background
Cristina Adriana Popa
Hunting Primary Hyperaldosteronism: are MRAs a ...

This week, we will continue with February’s aldosterone leitmotif: do mineralocorticoid receptor antagonists (MRAs) truly blind the diagnostic in unilateral hypraldosteronism? Is this the article the mythbuster? Draw your own conclusions

Hunting Primary Hyperaldosteronism: are MRAs a blindfold in adrenal vein sampling?
joel topf
June 29, 2020
Commentary

The PERL study visual abstract

joel topf
June 29, 2020
Commentary

Anju Yadav did a great job on the visual abstract for PERL.

Tagged: visual abstract, Visual Abstract, allopurinol

joel topf
June 29, 2020
Commentary

The CKD-Fix visual abstract

joel topf
June 29, 2020
Commentary

Arun Rajasekaran did a great job. I can’t believe it is his first visual abstract.

Tagged: visual abstract, Visual Abstract, allopurinol

joel topf
June 16, 2020
Commentary

Diagnosing Aldosteronism Visual Abstract

joel topf
June 16, 2020
Commentary

Samira Farouk did a great job with this week’s Visual Abstract

Tagged: aldo annals, aldosterone, hypertension, Hypertension, blood pressure

swapnil hiremath
June 16, 2020
Background

Diagnosing Aldosteronism

swapnil hiremath
June 16, 2020
Background
Diagnosing Aldosteronism

This week, we will discuss the correct way to diagnose primary aldosteronism. Is a spot ARR sufficient? Prepare to turn whatever you thought you knew about PA around.

Tagged: aldosterone, ali mehdi, krishna, annals, hypertension, observational, aldo annals

joel topf
May 26, 2020
Commentary

Empagliflozen is a diuretic? What? The Visual Abstract

joel topf
May 26, 2020
Commentary

Anju Yadav put together a stunning visual abstract for this week’s NephJC. Take a look.

Tagged: sglt mechanism, visual abstract, Visual Abstract

joel topf
May 26, 2020
Commentary

DAPA-HF, the Visual Abstract

joel topf
May 26, 2020
Commentary

OIn order to understand the significance of this week’s NephJC you should have more than a passing familiarity with DAPA-HF one of the foundational SGLT2i studies. To help you brush up here is a superior visual abstract by Sudha Mannemuddhu

Tagged: visual abstract, sglt mechanism, heart failure, SGLT2, Visual Abstract

swapnil hiremath
May 26, 2020
Background

SGLT2 inhibitors: Sweet (and Salty) Pee

swapnil hiremath
May 26, 2020
Background
SGLT2 inhibitors: Sweet (and Salty) Pee

SGLT2i are the wonder drug for our age. But do we know how they work? How does their natriuretic effect actually work? Let’s dig deeper into this week’s mechanistic study that explores this question

Tagged: sglt2i, wilson, agarwal, vlasschaert, circulation, sglt mechanism

Guest User
May 11, 2020
Background

No Pain for the Kidneys from NSAIDs

Guest User
May 11, 2020
Background
No Pain for the Kidneys from NSAIDs

This week, we discuss the latest from CRIC, an examination of NSAIDs versus opioids for patients with CKD. Join us May 12 and 13th to discuss with #NephJC.

Tagged: opioid, nsaid, cric, retrospective, ckd, anju yadav, lilia cervantes

joel topf
May 11, 2020
Commentary

NSAID vs Opioid in CKD, the Visual Abstract

joel topf
May 11, 2020
Commentary

Ali Mehdi comes up big for this week’s NephJC.

Tagged: nsaid v opioid, Visual Abstract, visual abstract, ali mehdi

swapnil hiremath
April 28, 2020
Commentary

Ischemia CKD: The Visual Abstract

swapnil hiremath
April 28, 2020
Commentary

Beautiful work from NSMC intern, Krishna Agarwal

The NEJM also did make a nice VA, in their own style

Tagged: ischemia ckd, visual abstract, Visual Abstract, krishna

swapnil hiremath
April 27, 2020
Background

Renalism Returns

swapnil hiremath
April 27, 2020
Background
Renalism Returns

This week, we will not discuss anything related to COVID. We know cardiovascular disease is the cause of most morbidity and mortality in CKD. Can an invasive approach benefit our patients?

Tagged: anju yadav, sudha, nejm, trial, rct, cardiovascular, ischemia ckd

swapnil hiremath
April 14, 2020
Background

COVID in the Kidney: An Autopsy Series

swapnil hiremath
April 14, 2020
Background
COVID in the Kidney: An Autopsy Series

This week, as an emergency chat, we will discuss some hot-off-the-press data. Published a few days ago, the first look at what happens in the kidneys.

Tagged: tiff caza, kidney international, biopsy, pathology, covidaki, covidautopsy, covid-19

swapnil hiremath
April 7, 2020
Commentary

MinTac: The Visual Abstract

swapnil hiremath
April 7, 2020
Commentary

The trial is from cJASN, so we do have a visual abstract from Pablo Garcia, in the cJASN style

And Omar as well created another visual abstract, in his own inimitable style

Tagged: visual abstract, mintac, Visual Abstract, cjasn, Garcia, Omar

swapnil hiremath
April 6, 2020
Background

Minimal Role for Steroids in Minimal Change Disease?

swapnil hiremath
April 6, 2020
Background
Minimal Role for Steroids in Minimal Change Disease?

Steroids are the mainstay of minimal change. Or are they? Lets explore an RCT that bravely challenges the status quo of steroids with tacrolimus monotherapy

Tagged: glomerulonephritis, trial, RCT, mcd, minimal change, tacrolimus, renua, jasn, mintac

swapnil hiremath
March 28, 2020
news, Commentary

TRANSPLANT

swapnil hiremath
March 28, 2020
news, Commentary
TRANSPLANT

This page discusses the common questions transplant professionals as well as transplant patients may have with COVID-19. We have few facts and little evidence, and those are laid out below. Locally, the decisions being taken depend on local resources, logistics and other factors, and hence local practice may appropriately vary.

Tagged: coronakidney, covid19, Transplant, Beje, Bea, Silvi

swapnil hiremath
March 25, 2020
Commentary, news

PEDIATRICS

swapnil hiremath
March 25, 2020
Commentary, news
PEDIATRICS

COVID-19, the disease caused by SARS-CoV-2, has rapidly become a global pandemic. This review aims to complement the other NephJC pages with a focus on how children with kidney disease are impacted by this pandemic. Our aim is to review what we know about COVID-19 as it pertains to kidney disease in kids.

Tagged: coronakidney, covid19, pediatrics, cathy quinlan, Rheault, Michelle Starr

joel topf
March 24, 2020
news

DIALYSIS and CKD

joel topf
March 24, 2020
news
DIALYSIS and CKD

The NephJC team is working to gather the most up to date and accurate information on how to do chronic dialysis in the middle of the pandemic.

Tagged: coronakidney, covid19, hemodialysis, dialysis

swapnil hiremath
March 21, 2020
Commentary, news

Byrd's Words: Preprints and Peer Review

swapnil hiremath
March 21, 2020
Commentary, news
Byrd's Words: Preprints and Peer Review

What is a preprint anyway? And how is it different from a ‘real’ research paper. What about reviews or perspectives?

Brian Byrd breaks it down for us

Tagged: preprints, Meta, byrd, byrdswords, covid-19

swapnil hiremath
March 21, 2020
Commentary, news

ACUTE KIDNEY INJURY

swapnil hiremath
March 21, 2020
Commentary, news
ACUTE KIDNEY INJURY

As with all the other pages on COVID-19 here on NephJC, this page on AKI & the discussion are not meant to be treatment recommendations based on sound evidence. Our aim on this page is to merely discuss the science of what we know, and some of the biology and mechanisms as well as practical management aspects.

Tagged: covid19, coronakidney, AKI, hiremath, jennie lin, covidaki

swapnil hiremath
March 14, 2020
news

ACE2 and HYPERTENSION

swapnil hiremath
March 14, 2020
news
ACE2 and HYPERTENSION

There has been an unprecedented interest in this topic. Hence we have added more details and moved this section from the main page to a dedicated area with focus on hypertension and ACE2. Curated by Matt Sparks and Swapnil Hiremath, with additional expert input from the COVID-ACE2 workgroup

Tagged: covid19, coronakidney, sars, ace, ace2, hypertension, sparks, hiremath, Hypertension, blood pressure

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