swapnil hiremath

September 8, 2020

Background

Can drug coating pop the balloon of dysfunctional dialysis access?

swapnil hiremath

September 8, 2020

Background

Can drug coating pop the balloon of dysfunctional dialysis access?

This week, we will discuss an unusual feature in nephrology: a trial in NEJM from nephrology that is positive. And on vascular access at that!

swapnil hiremath

August 24, 2020

Background

Rana Awdish's In Shock

swapnil hiremath

August 24, 2020

Background

Its book club time! We will be discussing Rana Awdish’s bestseller, the searing first person narrative of a doctor going through a critical illness. And almost dying.

swapnil hiremath

August 18, 2020

Background

Albuminuria = Proteinuria, Sorta?

swapnil hiremath

August 18, 2020

Background

This week, we will review the herculean task from the authors of the Annals paper, which examines whether PCR is just as good as ACR.

swapnil hiremath

August 4, 2020

Background

Time to Stop Starting RRT Early in AKI

swapnil hiremath

August 4, 2020

Background

This week, we will discuss the fresh-off-the-press STARRT AKI trial. The final, definitive trial to let us know about the timing of KRT in the ICU.

joel topf

July 14, 2020

Background

The Future is Now: Social Media in Seminars

joel topf

July 14, 2020

Background

The Future is Now: Social Media in Seminars

This week, we will discuss the social media issue in Seminars of Nephrology. The discussion will be anchored by two articles - but the whole issue is up for discussion.

swapnil hiremath

June 30, 2020

Background

Correlation is Confusion not Causation: The Case of Uric Acid in CKD

swapnil hiremath

June 30, 2020

Background

Correlation is Confusion not Causation: The Case of Uric Acid in CKD

This week, we will discuss the fresh-off-the-press trials from this week’s issue of the NEJM: PERL and CKD-FiX. These two trials examined if the uric acid and CKD link is causal: by measuring CKD progression after giving patients allopurinol. Be ready for another medical reversal.

swapnil hiremath

June 16, 2020

Background

Diagnosing Aldosteronism

swapnil hiremath

June 16, 2020

Background

This week, we will discuss the correct way to diagnose primary aldosteronism. Is a spot ARR sufficient? Prepare to turn whatever you thought you knew about PA around.

swapnil hiremath

May 26, 2020

Background

SGLT2 inhibitors: Sweet (and Salty) Pee

swapnil hiremath

May 26, 2020

Background

SGLT2i are the wonder drug for our age. But do we know how they work? How does their natriuretic effect actually work? Let’s dig deeper into this week’s mechanistic study that explores this question

Guest User

May 11, 2020

Background

No Pain for the Kidneys from NSAIDs

Guest User

May 11, 2020

Background

This week, we discuss the latest from CRIC, an examination of NSAIDs versus opioids for patients with CKD. Join us May 12 and 13th to discuss with #NephJC.

swapnil hiremath

April 27, 2020

Background

Renalism Returns

swapnil hiremath

April 27, 2020

Background

This week, we will not discuss anything related to COVID. We know cardiovascular disease is the cause of most morbidity and mortality in CKD. Can an invasive approach benefit our patients?

swapnil hiremath

April 14, 2020

Background

COVID in the Kidney: An Autopsy Series

swapnil hiremath

April 14, 2020

Background

This week, as an emergency chat, we will discuss some hot-off-the-press data. Published a few days ago, the first look at what happens in the kidneys.

swapnil hiremath

April 6, 2020

Background

Minimal Role for Steroids in Minimal Change Disease?

swapnil hiremath

April 6, 2020

Background

Minimal Role for Steroids in Minimal Change Disease?

Steroids are the mainstay of minimal change. Or are they? Lets explore an RCT that bravely challenges the status quo of steroids with tacrolimus monotherapy

Guest User

March 9, 2020

Background

ISPD Practice Recommendations 2020 - From ‘Patient’ to ‘Person’

Guest User

March 9, 2020

Background

ISPD Practice Recommendations 2020 - From ‘Patient’ to ‘Person’

This week, we will discuss the fresh-off-the-press ISPD recommendations on what they call as ‘prescribing high quality, goal directed’ PD. No mention of adequacy even in the title, in a subtle shade at the move away from numbers to things that really matter.

swapnil hiremath

February 24, 2020

Background

perPLEXed by ANCA? Let PEXIVAS show you the path to less steroids and the end of plasma exchange

swapnil hiremath

February 24, 2020

Background

perPLEXed by ANCA? Let PEXIVAS show you the path to less steroids and the end of plasma exchange

This week we discuss the long awaited PEXIVAS trial. Reduced dose steroids win, and PLEX loses. Or does it?

swapnil hiremath

February 11, 2020

Background

Are ANCA actually attackers?

swapnil hiremath

February 11, 2020

Background

We are now in GN territory this month - or rather ANCA Vasculitis month! First we start off with this paper from London, which uses some data from the RAVE trial along with additional experiments to show some intriguing results on the role of MPO.

joel topf

January 27, 2020

Background

GAD ain't BAD

joel topf

January 27, 2020

Background

In early 2000s there was an epidemic….and then it died down. Have we successfully eliminated the scourge of NSF by appropriately changing our behaviour? Perhaps the pendulum has swung too much and needs to come back to the middle.

swapnil hiremath

January 14, 2020

Background

Maybe MMF Measurement Matters?

swapnil hiremath

January 14, 2020

Background

We measure cyclosporine and tacrolimus levels. But don’t bother with mycophenolate levels - why is it? Is it too difficult? Does it not matter? NephJC tackles a different kind of study this time - a literature review, albeit conducted systematically.

swapnil hiremath

December 10, 2019

Background

Creatinine to Cystatin C: Time to Change?

swapnil hiremath

December 10, 2019

Background

Creatinine to Cystatin C: Time to Change?

This week, we will discuss a paper from Nature Medicine. Cystatin C has been around for a while, but not taken off in routine practice. Is it time for it to do so? In this study, authors from Glasgow using the UKBiobank data show that cystatin C improves the prediction of bad outcomes.

swapnil hiremath

November 25, 2019

Background

Repurposing old drugs: Mannitol for Intradialytic Hypotension

swapnil hiremath

November 25, 2019

Background

Repurposing old drugs: Mannitol for Intradialytic Hypotension

This week, we will discuss a pilot trial of using mannitol to treat intradialytic hypotension. A daily occurence in our practice, hence providing some much needed data.

joel topf

November 12, 2019

Background

Can difelikefalin scratch uremic pruritus?

joel topf

November 12, 2019

Background

Can difelikefalin scratch uremic pruritus?

This week we will be discussing the KALM-1 trial which was presented at the Late Breaking and High Impact Trial Session at the recently completed #KidneyWk. It was simultaneously published in the NEJM. Kalm-1 investigated whether difelikefalin, a opioid kappa agonist, decreased uremic pruritus.