The Freely Filtered Crew gave SONAR the PodCast treatment.
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This week, we will discuss a phase 2 trial of the TRPC6 inhibitor BI 764198 in FSGS—an early signal for a podocyte-targeted therapy showing proteinuria reduction but set against small numbers, heterogeneity, and methodological trade-offs that frame this as direction-finding rather than definitive evidence.
This week, we will discuss why a large registry cohort was needed to move past decades of scattered case reports and clarify the true risk of hydralazine‑associated vasculitis. When rare events hide in noise, only scale can reveal the signal. Can population‑level data finally bring this paradox into focus?
Summary of the STEPS trial which will be a twitter spaces discussion
This week, we will discuss the HIT trial- a large randomized study challenging one of the most reflexive responses in hospital medicine: see hyponatremia, fix the sodium. But what if correcting the number doesn’t change what actually matters?
The Freely Filtered Crew gave SONAR the PodCast treatment.
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The Freely Filtered crew get together for another podcast. This time it is a deep dive into MENTOR and mouse models, lots and lots of mouse models.
Nice visual abstract by Krithika Mohan. Excellent work.
An excellent visual abstract from Sinead Stoneman
Also check out the visual abstracts from Samira Farouk, Christhian Munoz, and the NEJM itself.
This week’s visual abstract on PREDNOS trial is by NSMC Intern Justin Davis.
The Freely Filtered team (minus Samira) spent an hour doing a deep dive on the Risk Score for IgA nephropathy and how many grams of IgA a human makes everyday.
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The Freely Filtered team (minus Swapnil) spent an hour doing a deep dive on the speed of sodium correction, the use of Slack in medicine. The Kardashian index, and misinformation on the internet. Take a listen. If you like it, leave us a review on iTunes.
This was NephJC’s first Tweetorial. We hope to make these regular components of the content NephJC generates to describe and disseminate the latest research.
1/ #Tweetorial #NephJC #Hypernatremia Reviews and guidelines say to correct hypernatremia in adults by no more than 10 mmol/L per day. This is based on little hard data, has little support in literature and may be harmful https://t.co/OlZHsSyHX1 pic.twitter.com/MZOBqgwZ40
— Nephrology Jrnl Club (@NephJC) May 15, 2019
NSMC Intern Daniyal Jafree stepped up to write an excellent tweetorial on the latest NephJC discussion. Take a look.
Welcome to the @NSMCInternship #tweetorial for this week’s study on a new risk prediction tool for IgA nephropathy, appearing in @JAMAInternalMed. Check out these unhappy glomeruli with mesangial IgA deposits in green from https://t.co/5t2NImFGj4 (1/16) pic.twitter.com/nDEkuxduK6
— Nephrology Jrnl Club (@NephJC) June 3, 2019