Freely Filtered 006 SONAR

The Filtrate (minus Matt) gather to talk about SONAR the randomized, placebo-controlled trial of atrasentan for the treatment of diabetic nephropathy.


Joel Topf

Jennie Lin

Samira Farouk

Swapnil Hiremath

Show Notes:

NephJC coverage of SONAR:

SONAR in PubMed:

Avosentan for overt diabetic nephropathy, the ASCEND trial:

RADAR coverage at NephJC, May 2014:

RADAR in PubMed:

Google Hangout on RADAR:

Vlado Perkovic:


Nephmadness adaptive trial:

KIDNEYcon adaptive trial tweet thread:

Excellent NEJM review on adaptive trials:

Potential role of Adaptive trials in AKI:

BNP levels in CKD:

Generalizability from Wikipedia:

Anemia (and other adverse effects of Endothelin antagonists)

Data safety monitoring boards:

AbbVie Allergen Merger:

Tangri Kidney Failure Risk Equation:

Fragility index paper

LITFL write up

Calculator (many) eg


Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study by David Juurlink et al.:

Vinay Prasad:

Classic mouse studies looking at endothelin:

Nice reviews:

Review of vascular effects: