Freely Filtered 007 MENTOR

The Filtrate (minus Samira) gather to talk about MENTOR the randomized trial of Rituximab versus cyclosporin for the treatment of idiopathic membranous nephropathy.

Cast:

Joel Topf

Jennie Lin

Matt Sparks

Swapnil Hiremath

Show Notes:

NephJC Coverage of MENTOR: http://www.nephjc.com/news/mentor 

MENTOR: https://www.nejm.org/doi/full/10.1056/NEJMoa1814427 

KDIGO Membranous recommendations: https://kdigo.org/wp-content/uploads/2017/02/KDIGO-2012-GN-Guideline-English.pdf 

2017 Kidney Week Abstract: https://www.asn-online.org/education/kidneyweek/2017/program-abstract.aspx?controlId=2831149

PEXIVAS: http://www.nephjc.com/news/pexivasearly

Heymann Nephritis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042693/

Susan Quaggin: https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=26269

Manasi Bapat on non-inferiority trials: http://www.nephjc.com/news/2019/7/8/understanding-the-vortex-of-non-inferiority-trials

Prognosis and risk factors for idiopathic membranous nephropathy with nephrotic syndrome in Japan: https://www.sciencedirect.com/science/article/pii/S0085253815498503

Nice review of Membranous by Alfaadhel and Cattrran that purports to say than CNI are the standard therapy for idiopathic membranous. (It doesn’t) https://www.ncbi.nlm.nih.gov/pubmed/27536673?dopt=Abstract 

Pablo Garcia saves the day: https://twitter.com/PabloGarciaMD/status/1148767319323099136?s=20 

Larry beck’s land mark study demonstrating antiPLA2r as the antigen in idiopathic membranous. https://www.nejm.org/doi/full/10.1056/NEJMoa0810457 

GEMRITUX Study: https://www.ncbi.nlm.nih.gov/pubmed/27352623 

Jennie Lin’s How to Be a Nephrology Fellow, Choose Your Own Adventure: https://twitter.com/jenniejlin/status/1156329711057981442?s=20 

CJASN How to Review a Paper Podcast: https://www.asn-online.org/media/podcast/CJASN/2019_07_23_How_to_Write_a_Cons.mp3 

Freely Filtered 006 SONAR

The Filtrate (minus Matt) gather to talk about SONAR the randomized, placebo-controlled trial of atrasentan for the treatment of diabetic nephropathy.

Cast:

Joel Topf

Jennie Lin

Samira Farouk

Swapnil Hiremath

Show Notes:

NephJC coverage of SONAR: http://www.nephjc.com/news/sonar

SONAR in PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30995972

Avosentan for overt diabetic nephropathy, the ASCEND trial: https://www.ncbi.nlm.nih.gov/pubmed/20167702

RADAR coverage at NephJC, May 2014: http://www.nephjc.com/atrasentan

RADAR in PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24722445/

Google Hangout on RADAR: https://www.youtube.com/watch?v=pkkQbb-isog&feature=youtu.be

Vlado Perkovic: https://twitter.com/VladoPerkovic

SONAR: https://en.wikipedia.org/wiki/Sonar

Nephmadness adaptive trial: https://ajkdblog.org/2016/03/10/nephmadness-2016-statistics-in-nephrology-region/#adaptive

KIDNEYcon adaptive trial tweet thread: https://twitter.com/hswapnil/status/1117194018331471873?s=21

Excellent NEJM review on adaptive trials: https://www.nejm.org/doi/10.1056/NEJMra1510061

Potential role of Adaptive trials in AKI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869991/

BNP levels in CKD: https://cjasn.asnjournals.org/content/3/6/1644

Generalizability from Wikipedia: https://en.wikipedia.org/wiki/Generalizability_theory

Anemia (and other adverse effects of Endothelin antagonists) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210319/

Data safety monitoring boards: https://www.nidcr.nih.gov/research/human-subjects-research/interventional-studies/data-and-safety-monitoring-board-guidelines

AbbVie Allergen Merger: https://www.barrons.com/articles/abbvie-allergan-merger-pharma-deals-takeda-celgene-bristol-myers-squibb-51563890831

Tangri Kidney Failure Risk Equation: https://qxmd.com/calculate/calculator_308/kidney-failure-risk-equation-4-variable

Fragility index paper https://www.ncbi.nlm.nih.gov/m/pubmed/24508144/

LITFL write up https://litfl.com/fragility-index/

Calculator (many) eg https://clincalc.com/Stats/FragilityIndex.aspx

CANVAS Trial: https://www.nejm.org/doi/full/10.1056/NEJMoa1811744

Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study by David Juurlink et al.: https://www.nejm.org/doi/full/10.1056/NEJMoa040135

Vinay Prasad: https://en.wikipedia.org/wiki/Vinay_Prasad

Classic mouse studies looking at endothelin: https://www.jci.org/articles/view/119297/pdf
https://www.ncbi.nlm.nih.gov/pubmed/8377387/
https://diabetes.diabetesjournals.org/content/65/8/2429

Nice reviews:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698004/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216619/

Review of vascular effects:
https://www.ncbi.nlm.nih.gov/pubmed/28223322

Freely Filtered 005 IgA Nephropathy

The Filtrate (minus Samira) gather to talk about predicting the natural (or not so natural history) of IgA nephropathy.

Cast:

Joel Topf

Jennie Lin

Matt Sparks

Swapnil Hiremath

Show Notes:

Levi Strauss: https://www.biography.com/fashion-designer/levi-strauss

Levey MDRD study: https://www.ncbi.nlm.nih.gov/pubmed/10075613

ADPKD Total Kidney Volume: https://www.nejm.org/doi/10.1056/NEJMoa054341

Halt PKD: https://www.nejm.org/doi/full/10.1056/nejmoa1402685

Tempo 3:4 Trial: https://www.nejm.org/doi/full/10.1056/NEJMoa1205511

Description description of IgA nephropathy by Berger and Hiunglais: https://www.ncbi.nlm.nih.gov/pubmed/4180586

The reprint in JASN in 2000 with commentary as part of the Milestones in Nephrology series: https://jasn.asnjournals.org/content/jnephrol/11/10/1957.full.pdf JASN supplies an English translation from the original French.

Nice reference from JASN backing up Matt’s assertion that preeclampsia and not IgA nephropathy is the most common glomerular disease in the world: https://jasn.asnjournals.org/content/18/8/2281

Description of the Singapore Army screening recruits from the Oxford Textbook of Clinical Nephrology: https://books.google.com/books?id=fVItBQAAQBAJ&lpg=PA485&ots=JRoOnUnleT&dq=singapore%20kidney%20biopsy%20army&pg=PA485#v=onepage&q&f=false

Description of the Japanese glomerulonephritis screening program: https://cjasn.asnjournals.org/content/2/6/1360

Swapnil’s studies on autopsy studies:

Finland: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC501386/

Japan: https://www.ncbi.nlm.nih.gov/pubmed/12753320/


Nephrology Secrets, either one of the best or the best nephrology textbooks ever: https://www.amazon.com/Nephrology-Secrets-Book-Edgar-Lerma-ebook/dp/B079TSYNQW/ref=sr_1_1

TESTING Trial on NephJC: http://www.nephjc.com/news/2017/8/28/testing


Stop-Iga Trial on NephJC: http://www.nephjc.com/iga-nephropathy


Testing Trial two: Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study Low Dose Study: https://clinicaltrials.gov/ct2/show/NCT01560052


MEST Score versus MEST-C in NephJC: http://www.nephjc.com/news/2016/10/16/do-crescents-matter-for-iga-nephropathy


Nice discussion of the statistical tests during the Tweet Chat by people who know their stats (I.e. not Joel): https://twitter.com/NephJC/status/1133546750814367746


Tweet-length description of IDI: https://twitter.com/kiwiskiNZ/status/1133595698929098752


Assessing the performance of prediction models: a framework for traditional and novel measures. https://www.ncbi.nlm.nih.gov/pubmed/20010215/


Net Reclassification Indices for Evaluating Risk-Prediction Instruments: A Critical Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918180/


Predicting Progression in CKD: Perspectives and Precautions https://www.ajkd.org/article/S0272-6386(15)01413-4/abstract


The Article by Nancy Cook in Circulation that Jennie was talking about: Use and misuse of the receiver operating characteristic curve in risk prediction. https://www.ncbi.nlm.nih.gov/pubmed/17309939

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens https://www.nature.com/articles/ng.3118

Genome-wide polygenic risk predictors for kidney disease https://www.nature.com/articles/s41581-018-0067-6


Where does Matt find minutia like the grams of IgA produced a day? Here: https://www.annualreviews.org/doi/abs/10.1146/annurev-pathol-011110-130216

Animal models of IgA nephropathy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337240/

Matt’s Book Originals: https://www.amazon.com/gp/product/014312885X/ref=dbs_a_def_rwt_bibl_vppi_i1

Eric Neilson, Dean of Northwestern University https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=23239

Brussels sprout Insta-famous dog and future dean of the medical school: https://www.instagram.com/brussels.sprout/?hl=en

Josh Farkas Rantorial about Contrast Nephropathy: https://twitter.com/PulmCrit/status/1134922050794139648

Swapnil’s Tweetorial about Contrast Nephropathy: https://twitter.com/hswapnil/status/1133906398096609280

Tukaram’s pic of NEJM’s progression from Contrast Induced Nephropathy to Contrast Associated Nephropathy: https://twitter.com/tukaramj/status/1135214980985266178

Zero sodium dialysate for heart failure? https://twitter.com/i/moments/1134811009217155072

Freely Filtered 004 Hypernatremia

The Filtrate (minus Swapnil) gather to talk about the treatment of hypernatremia.


Show Notes:

Joel Topf

Jennie Lin

Matt Sparks

Samira Farouk

 

The strange story of Jennifer Strange.

https://insiderexclusive.com/radios-deadly-stunts-the-jennifer-strange-story/


Water Poker

https://www.thelocal.se/20120706/41878


 Nintendo Game Consoles

https://en.wikipedia.org/wiki/Nintendo_video_game_consoles


2019 Narins winner, Mitchel Rosner on MDMA induced hyponatremia

https://www.ncbi.nlm.nih.gov/pubmed/18684895


And Rosner again on exercise induced hyponatremia.

https://cjasn.asnjournals.org/content/2/1/151


The Arieff article on the dangers of severe hyponatremia: Hyponatremia, Convulsions, Respiratory Arrest, and Permanent Brain Damage after Elective Surgery in Healthy Women

https://www.nejm.org/doi/full/10.1056/NEJM198606123142401


The Richard Sterns article on the dangers of rapid correction of hyponatremia: Osmotic Demyelination Syndrome Following Correction of Hyponatremia

https://www.nejm.org/doi/10.1056/NEJM198606123142402

The editorial by the man himself, Robert Narins: Therapy of Hyponatremia

https://www.nejm.org/doi/full/10.1056/NEJM198606123142409


The infant study showing seizures associated with rapid correction of hypernatremia.

https://www.ncbi.nlm.nih.gov/pubmed/35558?dopt=Abstract


Follow up study with oral rehydration.

https://www.ncbi.nlm.nih.gov/pubmed/3958850?dopt=Abstract


The Linder study of adults admitted to the ICU

https://www.ncbi.nlm.nih.gov/pubmed/18037096


French study on patients presenting to the ER with hypernatremia.

https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-15-37


Study on US veterans showing poorer outcomes with slow correction of hypernatremia. 

https://www.ncbi.nlm.nih.gov/pubmed/21358313


Cerebral edema during the treatment of DKA.

https://emj.bmj.com/content/21/2/141


The MIMIC 3 Database. MIMIC is an openly available dataset developed by the MIT Lab for Computational Physiology, comprising deidentified health data associated with ~40,000 critical care patients. It includes demographics, vital signs, laboratory tests, medications, and more.

https://mimic.physionet.org


Chalrson Comorbidity Index

https://www.mdcalc.com/charlson-comorbidity-index-cci#creator-insights

The paper: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.

https://www.ncbi.nlm.nih.gov/pubmed/3558716


JCI article on organic brain osmnoles in response to hypernatremia

https://www.ncbi.nlm.nih.gov/pubmed/2332498?dopt=Abstract

John Booth on the value of MIMIC 3

https://twitter.com/ThePeanutKidney/status/1128742219471642624

Sri Lekha on checking labs in hypernatremia

https://twitter.com/LTummalapalli/status/1128479041634226176

Steve Coca on chunky water administration

https://twitter.com/scoca1/status/1128744643422769152

Steve Coca musing the Cersei’s sodium level

https://twitter.com/scoca1/status/1128698514026975232

Steve Coca swearing in High Valarlian:

https://twitter.com/scoca1/status/1128629713826721792

Steve Coca proving the non-existence of hypernatremia therapy being associated with brain damage through the inability of trial lawyers to find and sue doctors for this issue:

https://twitter.com/scoca1/status/1128652586612080642



The original paper on the Kardashian Index

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0424-0

Kardashian Index Calculator

http://theinformationalturn.net/kardashian-index/



Facebook CEO Mark Zuckerberg says the ‘future is private’

https://www.theverge.com/2019/4/30/18524188/facebook-f8-keynote-mark-zuckerberg-privacy-future-2019

Khenar Jhaveri et al on ‘WhatsApp’ening in nephrology training

https://academic.oup.com/ckj/advance-article/doi/10.1093/ckj/sfz045/5482109



Mike Morrison’s video on how to rebuild the scientific poster

https://www.youtube.com/watch?v=1RwJbhkCA58

Mike’s Twitter: https://twitter.com/mikemorrison?lang=en with lot’s of examples of his design in the wild.

Make your own QR code: https://www.qr-code-generator.com



GoodRx: https://www.goodrx.com

Ten Worst Drugs for your Kidney: https://www.goodrx.com/blog/10-worst-medications-for-your-kidneys/

Drugs that can falsely elevate your creatinine levels: https://www.goodrx.com/blog/drugs-cause-false-high-creatinine-levels-blood-test/

Dr Orrange, not wishing to engage on Twitter in a meaningful way: https://twitter.com/Orrangemd/status/1129165083194511361