FF 87 Can Fish Oil Knock the Crap out of Dialysis Associated CV Disease?
The Filtrate
Joel Topf @kidneyboy.bsky.social (COI)
Swapnil Hiremath @hswapnil.medsky.social and on LinkedIn
Pedro Teixeira @nephcrit.bsky.social
Special Guests
Charmaine E Lok, MD Professor of Medicine at the Faculty of Medicine, University of Toronto
Editing and Show Notes by
Joel Topf
The Kidney Connection written and performed by Tim Yau
Show Notes
Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis NEJM | NephJC
What works in hemodialysis?
Iron: PIVOTAL Trial (NEJM)
Hemodiafiltration: CONVINCE (NEJM)
Earlier work on vascular access, The FISH Trial: Effect of fish oil supplementation on graft patency and cardiovascular events among patients with new synthetic arteriovenous hemodialysis grafts: a randomized controlled trial JAMA
Eskimo myth: "Fishing" for the origins of the "Eskimos and heart disease" story: facts or wishful thinking? (PubMed)
Dialysis patients have low levels of fish oil in their body (PubMedCentral)
Positive trial in non-dialysis patients: REDUCE-IT
Negative trial of fish oil in non-dialysis patients: STRENGTH
ACC does not recommend FISH Oil for primary or secondary prevention of CV events (ACC)
Poisson distribution (Wikipedia)
Ocean Nutrition Canada (Wikipedia)
Ocean Nutrition was bought by DSM (Press Release)
DSM merged with Firmenich (Press Release)
Vanguard feasibility trials (PubMed)
Freezing fish oil caps will eliminate the fishy aftertaste (Pharmacists Letter)
The study also received a philanthropic donation from Mr. Alexander Epstein (UHN Research)
Selection Bias, Interventions and Outcomes for Survivors of Cardiac Arrest (PubMedCentral)
Consort Diagram
Effectiveness of fish oil in controlling inflammation in adult patients undergoing hemodialysis: A systematic review and meta-analysis (PubMed)
Tubular Secretions
Swapnil Hiremath: Michael Clayton (IMDB)
Pedro: Fifa World Cup Soccer coming to North America with Portugal! (FIFA)
Charmaine: New Puppy, Rose. It’s a Barbet (Wikipedia)
Joel Topf: The Dark Forrest by Liu Cixin (Wikipedia)