TWiN (The Week in Nephrology) 22 Aug 2016


Several observational studies have suggested extended hours hemodialysis has survival outcomes. To add to that literature another study published recently in Kidney International compared survival outcomes of extended hours hemodialysis to conventional hemodialysis incenter. There was a 33% lower risk of all cause mortality in patients on extended hours dialysis.

An interesting observation was made from a recently published systematic review and meta analysis by @Wisit661 . In this recent publication inCanadian Journal of Diabetes the data suggestsa 1.9 fold increase in New Onset Diabetes After Transplantation(NODAT) in patients with ADPKD. Whether these patient would require insulin for treatment was no different in the groups. 

Published this week in the Annals of Internal Medicine the ACP Journal club discusses the findings of subgroup analysis of the #SPRINT trial originally published in JAMA.  In patients >75 years old(mean =  82), intensive lowering of blood pressure (<120) compared to standard (<140) resulted in lower cardiovascular events (7.7% vs 11.2%) and lower all cause mortality ( 5.5% v 8.1%). The adverse effects in symptomatic hypotension, falls, syncope, electrolyte abnormalities was higher but not statistically significant.

Another win for SGLT2 inhibitors, this time cangliflozin was shown to reduce the rate of CKD progression in diabetic patients. This was published in JASN.

An excellent review in Nature Reviews on Idiopathic hypercalciuria and the pathophyisology of calcium nephrolithiasis.


Deviating from the regular tidbits that I include here - this week I came across a nice blog postby a Dialysis nurse which I thought worth including - Read it here - "A view from the other end of the dialysis needle".


- Nikhil Shah (@dr_nikhilshah)