Episode 025: Albumin to creatinine ratio (ACR) is the gold standard for assessing proteinuria, however many doctors, due to habit or necessity, measure a protein to creatinine ratio (PCR) or just assess proteinuria with a urine dip stick. This study brings a way to convert those methods to an equivalent ACR. Or does it? Listen on…
The Filtrate:
Matt Sparks
Joel Topf
Swapnil Hiremath
Jennie Lin
Jordy Cohen
And two special guests:
Morgan Grams, study author.
Talar Kharadjian, nephrology fellow UC San Diego
Show Notes:
History of albuminuria from Matt’s opening monolog: https://academic.oup.com/ndt/article/18/7/1281/1809803
Microalbuminuria As A Predictor Of Clinical Nephropathy In Insulin-Dependent Diabetes Mellitus in the Lancet 1982.
Microalbuminuria Predicts Clinical Proteinuria and Early Mortality in Maturity-Onset Diabetes in the NEJM 1984
Episode of Freely Filtered with Dr. Feldman, the big guy at the top of the CRIC trial: NSAIDs vs Opioids.
The Aldo study where they didn’t do a meta-analysis but they should have: Aldosteronism is everywhere.
Estimating Urine Albumin-to-Creatinine Ratio from Protein-to-Creatinine Ratio: Development of Equations using Same-Day Measurements. Canadian data. CJASN
The kidney failure risk equation has a dotcom: https://kidneyfailurerisk.com
KDIGO Controversies Conference on Early Identification & Intervention in CKD
Choose Your Own Adventure: Cave of Time.
Witte et al. in 2009 JASN on first morning urine vs 24 hour collection: First Morning Voids Are More Reliable Than Spot Urine Samples to Assess Microalbuminuria
Sensitivity and specificity for Joel to study
Your Manuscript On Peer Review
Nephrology Business Leaders University (NBLU)
Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach with lead author Catherine Clase
Elimination or Prolongation of ACE Inhibitors and ARB in Coronavirus Disease 2019 (REPLACECOVID)
Fast Grant. Apparently they are not just for Brian Byrd
NephJC ACE2 Stuff as Jordy calls it: http://www.nephjc.com/news/covidace2
The BRACE-CORONA trial a 700 person RCT of ACEi and ARB in Covid-19. No effect. Tweet stream by Swapnil.
MC Hammer is a science nerd: https://cen.acs.org/education/science-communication/Hammer-time-Science-Twitter-drummers/98/i31
Hammerman origin story for the MC Hammer cartoon.
Bowman Society Lecture - Race & Renal Function Calculations
Basic Research Forum for Emerging Kidney Scientists: A Partnership Between APS and ASN