Freely Filtered 062: Inaxaplin for APOL1 Kidney Disease

Freely Filter goes where we have never gone before…a Phase 2 trial!

The Filtrate:

Joel Topf

Jennie Lin

Josh Waitzman

With Special Guest:

AC Gomez MedPeds nephrology fellow at Mass General/Brigham and Boston Children’s | Twitter

Gentian Hall Assistant Professor of Medicine Duke Department of Medicine

Editor:

Sophia Ambruso

Show Notes:

APOL1 review by the OG Scientists APOL1 Nephropathy: From Genetics to Clinical Applications

MYH9 and APOL1 connection: The population genetics of chronic kidney disease: insights from the MYH9–APOL1 locus

Martin Pollack Lab

Vertex Lab

Worldwide Frequencies of APOL1 Renal Risk Variants (NEJM)

Kidney Disease-Associated APOL1 Variants Have Dose-Dependent, Dominant Toxic Gain-of-Function

End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated With APOL1

Apolipoprotein L1 Risk Variants Associate with Systemic Lupus Erythematosus-Associated Collapsing Glomerulopathy

HEK293 Cells Wikipedia

Tubular Secretions

Josh: From Serial and the New York Times: The Retrievals

Jennie: Marathon induced hyponatremia (NEJM)
Donate to the NKF of Illinoise in honor of Jennie’s really long run
Donate to New England Donor Services in honor of Josh’s much shorter ruin

Gentian: Vivien Thomas wikipedia. HBO Movie: Something the Lord Made

AC: Talking to the FDA about SGLT2i Tweet

Joel: NephJC 2023 Fund drive