FSGS is hard and the data sucks. But here comes sparsentan fresh off its win in the PROTECT trial for IgA Nephropathy. Can it pull another rabbit out of the hat for patients that suffer from FSGS or are we doomed to forever treating our patients with Acthar® Gel?
Freely Filtered 065: BEST Fluids
Freely Filtered 062: Inaxaplin for APOL1 Kidney Disease
Freely Filtered 061: Bicarb in Transplant
Freely Filtered 059: Furosemide v Torsemide
Freely Filtered 060: HCTZ v Kidney Stones, The NOSTONE trial
Freely Filtered 056: MyTEMP
Freely Filtered 053: The Kidney Week Draft
Freely Filtered 052: Acetazolamide for Acute Decompensated Heart Failure (ADVOR)
Freely Filtered 049: Getting Salty with SODIUM-HF
Freely Filtered 047: CHAP, time to treat hypertension in pregnancy
Freely Filtered 046: The ISPD Peritonitis Guideline Draft
Freely Filtered 045: Salt Substitution and Stroke Study (SSaSS)
Freely Filtered 044: Pigs on the Wing: Xenotransplantation
Freely Filtered 043: NephMadness and Animal House
Freely Filtered 042: Nephrin Antibodies Cause Minimal Change Disease. Wait...What?
Freely Filtered 039: The First Annual ASN #KidneyWk Draft
Freely Filtered 038: AURORA1, a new treatment for Lupus Nephritis
Freely Filtered 037: The first Guideline Draft: KDIGO Hypertension Guidelines
Freely Filtered 036: AKIKI-2, How soon is now?
Episode 036 AKIKI-2. Nephrology has been the beneficiary of a handful of studies examining the impact of the timing of the initiation of dialysis in AKI. One of these trials, AKIKI, now has a genuine sequel. In 2016 AKIKI was the first multi-center RCT examining early initiation of dialysis versus late initiation of dialysis and showed that early initiation not only failed to improve patient outcomes but resulted in a significant number of patients receiving dialysis that would have recovered kidney function without intervention had they only been randomized to the late arm. Now five years later we are reviewing the sequel which asks the next logical question, “If delayed dialysis is as good as early dialysis is even later dialysis equivalent or even better?”