Freely Filtered 060: HCTZ v Kidney Stones, The NOSTONE trial

Another dogma shredding trial about diuretics, this time hydrochlorothiazide ability to reduce symptomatic kidney stone events and kidney stone growth goes on trial.

The Filtrate:

Joel Topf

Swapnil Hiremath

Josh Waitzman

Nayan Arora

Sophia Ambruso

With Special Guest:

Megan Prochaska Assistant professor of medicine at University of Chicago

John Asplin Medical Director Consultant LithoLink (Twitter)

Editor:

Joel Topf

Show Notes:

The LithoLink website

Stone Camp tweet

Prevention of Repeated Episodes of Kidney Stones in Adults: A Clinical Practice Guideline From the American College of Physicians (link)

NOSTONE in the NEJM and NephJC

Fred Coe Google Scholar | YouTube | Blog

Hypercalcuria. Curhan et al. 24-h uric acid excretion and the risk of kidney stones PubMed

EQUIL2 software to evaluate urinary super saturation

Anna Zisman Racial Differences in Risk Factors for Kidney Stone Formation (CJASN)

Potassium Citrate on GoodRx

Moonstone Nutrition

Potassium and citrate by Fred Coe (blog)

Thiazide Diuretics and Fracture Risk: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials (PubMed)

Chlorthalidone promotes mineral retention in patients with idiopathic hypercalciuria by Coe et al (PubMed)

NHANES 24-hour urine Na (Abstract)

Kidney Stone risk is reduced with empagliflozin (PubMed)

Prospective trial to determine the effect of SGLT2i on urinary supersaturation (BMJ Open)

GLP agonists and kidney stone risk

Tubular Secretions

Swap: Star Wars: Thrawn Series by Timothy Zahn (Penguin Random House)

Josh: Little League

Megan: Renal related podcasts

Sophia Renal Stone Camp and ABCKidney.com

Nayan: Ted Lasso Robert Galbraithand The Comoran Strike Novels (home page)

John: Fred Coe’s Blog

Joel: Spiderman across the Spider-Verse (Wikipedia)