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The NephJC Kidneys return for the fourth year. Time for #NephTwitter to nominate their favs.
Some cases of ADTKD are due to mutations of the MUC-1 gene, one mutation is a frame shift mutation that results in a premature stop codon. which results in accumulation of the abnormally short, and toxic protein MUC-1 fs . The researchers found a small protein, BRD4780, that reroute MUC-1fs to lysosomes, preventing proteinopathy and possibly altering the natural history of the disease.
This week is a joint #DermJC and #NephJC. We will discuss two articles - here is the summary of the larger case series, from Vandana Niyyar.
The Freely Filtered team (minus Samira) spent an hour doing a deep dive on the Risk Score for IgA nephropathy and how many grams of IgA a human makes everyday.
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NSMC Intern Daniyal Jafree stepped up to write an excellent tweetorial on the latest NephJC discussion. Take a look.
Welcome to the @NSMCInternship #tweetorial for this week’s study on a new risk prediction tool for IgA nephropathy, appearing in @JAMAInternalMed. Check out these unhappy glomeruli with mesangial IgA deposits in green from https://t.co/5t2NImFGj4 (1/16) pic.twitter.com/nDEkuxduK6
— Nephrology Jrnl Club (@NephJC) June 3, 2019
