In this edition of NephJC, we discuss the largest case series of kidney biopsies in patients with Diabetes.
This week we will discuss whether a bundled, team-based hypertension intervention- featuring intensive BP targets, home monitoring, health coaching, and audit feedback- can overcome poverty, clinical inertia, and fragmented care to improve blood pressure control in low-income patients receiving care at federally qualified health centers.
This week, we will discuss a phase 2 trial of the TRPC6 inhibitor BI 764198 in FSGS—an early signal for a podocyte-targeted therapy showing proteinuria reduction but set against small numbers, heterogeneity, and methodological trade-offs that frame this as direction-finding rather than definitive evidence.
This week, we will discuss why a large registry cohort was needed to move past decades of scattered case reports and clarify the true risk of hydralazine‑associated vasculitis. When rare events hide in noise, only scale can reveal the signal. Can population‑level data finally bring this paradox into focus?
¿Hemos subestimado la frecuencia de la nefrópatía no diabética (NND) en pacientes diabeticos? Una cohorte basada en biopsias renales de 49,075 pacientes refuerza cuán heterogénea puede ser la NND y destaca las características clínicas más asociadas con la NND. ¿A quién debemos biopsiar? ¿Cuándo debemos sospecharla? ¿Cómo puede la histología cambiar el pronóstico?
Acompáñanos este martes en la discusión de #NephJC.
Have we been underestimating NDKD in patients with diabetes? A biopsy-based cohort of 49,075 patients reinforces just how heterogeneous kidney disease can be in DN and highlights the clinical features most strongly associated with NDKD. So, who should we biopsy? When should we suspect NDKD? And how can histology change prognosis?
Join us for this tuesday on the #NephJC discussion
Should we call 2024 the Renaissance of nephrology? It was probably the richest year in RCTs in the nephrology world, reflected in the higher number of Late-Breaking Clinical Trials sessions at every big nephrology congress. Probably 1st place won’t surprise anyone; it was the anticipated FLOW of the year, but this Top 10 Nephrology Stories definitely includes some unexpected titles
Huge news in APOL1 nephropathy - ten tweets to fill you in here:
Welcome to #TenTweetNephJC
— Nephrology Journal Club (@NephJC) May 12, 2023
✳️10 tweets #NephJC catch-up ✳️
On 4/25-26, we discussed the phase II study examining inaxaplin treatment, a small molecule inhibitor, in APOL1 nephropathy. This is the first drug specifically targeting this disease.
Join us here for the recap! pic.twitter.com/LApAHkYn10
Check out the tweetorial for the MAIN event - does MMF work in IgA Nephropathy?
Welcome to #TenTweetNephJC!
— Nephrology Journal Club (@NephJC) April 28, 2023
✳️10 tweets #NephJC catch-up ✳️
On 3/28-29, #NephJC reviewed the MAIN trial (Mycophenolate monotherapy in IgA Nephropathy). Here are some pearls from the chat ⬇️ pic.twitter.com/RUepFSEwXx
Ten Tweet round up of exciting CAR T trial in patients with SLE discussed last month - check it out while you can!
Welcome to #TenTweetNephJC
— Nephrology Jrnl Club (@NephJC) November 18, 2022
✳️ 10 tweets #NephJC catch-up ✳️
Here’s a recap of our 25th Oct #NephJC discussion on ‘Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus’ - better late than never!
Check out the paper at https://t.co/HxTcVC3PtH pic.twitter.com/y7o71HUPiZ
Did you miss the TESTING reboot discussion? No worries, we have you covered here:
Welcome to #TenTweetNephJC where we will be discussing the largest randomized, placebo controlled trial of steroid treatment in IgA nephropathy patients.
— Nephrology Jrnl Club (@NephJC) June 21, 2022
✳️ 10 tweets #NephJC catch-up ✳️ pic.twitter.com/kRdt91F8gq
