Background
Cristina Adriana Popa
Is TRPC6 inhibition for FSGS a trick or a treat?

This week, we will discuss a phase 2 trial of the TRPC6 inhibitor BI 764198 in FSGS—an early signal for a podocyte-targeted therapy showing proteinuria reduction but set against small numbers, heterogeneity, and methodological trade-offs that frame this as direction-finding rather than definitive evidence.

Is TRPC6 inhibition for FSGS a trick or a treat?
Background
Cristina Adriana Popa
Why-dralazine?! Population risk of drug induced ...

This week, we will discuss why a large registry cohort was needed to move past decades of scattered case reports and clarify the true risk of hydralazine‑associated vasculitis. When rare events hide in noise, only scale can reveal the signal. Can population‑level data finally bring this paradox into focus?

Why-dralazine?! Population risk of drug induced vasculitis
Background
Cristina Adriana Popa
From missed opportunities to equitable access: ...

Summary of the STEPS trial which will be a twitter spaces discussion

From missed opportunities to equitable access: Can STEPS redesign the kidney transplant pathway?
Background
Cristina Adriana Popa
Searchin’ For My Lost Shaker of Salt- Targeted ...

This week, we will discuss the HIT trial- a large randomized study challenging one of the most reflexive responses in hospital medicine: see hyponatremia, fix the sodium. But what if correcting the number doesn’t change what actually matters?

Searchin’ For My Lost Shaker of Salt- Targeted Treatment of Hyponatremia
news
swapnil hiremath
NephJC Covers LBCTs at the World Congress

The NephJC editors cover the simultaneous publication from the world congress

DIvya Bajpai

TRPC6 inhibition: The Visual Abstract

For the first time, a podocyte-targeted therapy shows clinical efficacy in FSGS. This week #NephJC covers the phase 2 RCT of BI 764198, an oral TRPC6 inhibitor that lowered proteinuria, preserved eGFR, and was well tolerated. A new era in FSGS? Check out the visual abstract by Divya Bajpai

Can hydralazine trigger ANCA vasculitis?

A large registry cohort was essential to move beyond scattered case reports and finally quantify the true risk of hydralazine‑associated vasculitis. When rare events blur into background noise, only scale can clarify the signal. Can population‑level data sharpen the picture?

Check out Divya Bajpai VA

¿Es eficaz la desmopresina para reducir el riesgo de sangrado tras una biopsia renal?

¿Cuál es la eficacia de la desmopresina tras la biopsia renal?
Prasad et al muestra una reducción significativa de sangrado. ¿Será el beneficio consistente según los subgrupos de acuerdo a la TFGe? Revisa el resumen visual creado por Divya Bajpai.

Obinutuzumab en Nefritis Lúpica: ¿Un Nuevo Horizonte?

El estudio REGENCY, un ensayo fase 3, doble ciego y controlado con placebo, evaluó la eficacia y seguridad de obinutuzumab en pacientes con nefritis lúpica activa. ¿Es realmente eficaz y seguro en la depleción de células B en LN?
🔥 Hoy en #NephJC analizamos cómo estos hallazgos impactarán el futuro del tratamiento en la nefritis lúpica. 🕘 Únete a la discusión a las 9 pm EST en BlueSky🦋!

Mineralocorticoid Receptor Blockade prior to Adrenal Venous Sampling for PA - The Visual Abstract

Do Mineralocorticoid Receptor Antagonists Preclude the Identification of Unilateral Primary Aldosteronism at Adrenal Venous Sampling?

Guidelines recommend withholding MRAs prior to PA subtyping by AVS. Is it worth the risk of hypokalemia and hypertension? NSMC Faculty Dr Divya Bajpai answers with a crisp VA