This week, we will discuss SODaBIC trial: with ICU acidosis driven by multiple overlapping mechanisms, is bicarbonate infusion supported by robust evidence, or does it persist mainly out of habit rather than physiology?
Beyond Diabetic Kidney Disease: FIND-ing Finerenone's Next Role
FIND-CKD extends finerenone beyond diabetic kidney disease, showing slower eGFR decline and sustained albuminuria reduction in non-diabetic CKD. While the benefits are modest and cardiovascular effects remain uncertain, the trial opens the door to broader use of nsMRAs and raises important questions about combination therapy with SGLT2 inhibitors.
On the right TRACK? Rivaroxaban to prevent cardiovascular events in advanced CKD.
NephJC Short: Bayesian leash: How a prior walked the Tigris across the finish line
Inhibidor de TRPC6: El Resumen Visual
Por primera vez, una terapia dirigida al podocito muestra eficacia clínica en GEFyS. Esta semana #NephJC revisa el ECA fase 2 de BI 764198, inhibidor oral de TRPC6, que redujo proteinuria, estabilizó el FGe y fue bien tolerado. ¿El inicio de una nueva era en GEFyS? Revisa el resumen visual por la Dra Divya Bajpai
TRPC6 inhibition: The Visual Abstract
For the first time, a podocyte-targeted therapy shows clinical efficacy in FSGS. This week #NephJC covers the phase 2 RCT of BI 764198, an oral TRPC6 inhibitor that lowered proteinuria, preserved eGFR, and was well tolerated. A new era in FSGS? Check out the visual abstract by Divya Bajpai
Searchin’ For My Lost Shaker of Salt- Targeted Treatment of Hyponatremia
NephJC Covers LBCTs at the World Congress
INFINITI: The Visual Abstract
SGLT2i have reshaped cardiorenal care, but kidney transplant recipients have mostly been left out of the story. INFINITI starts to close that gap, testing the safety and physiology of dapagliflozin in stable KTR.
Do #flozins behave the same in transplanted kidneys? Check out the VA by Janany Sabescumar
INFINITI: El Resumen Visual
Los iSGLT2 han revolucionado la protección cardiorrenal, pero los trasplantados renales han quedado fuera de la historia. El ensayo INFINITI empieza a cerrar esa brecha. ¿Flozinaran igual los iSGLT2 en el riñón trasplantado? Revisa el resumen visual creado por Janany Sabescumar
To INFINITI and Beyond: SGLT2 Inhibitors in Kidney Transplant Patients
POTCAST: The Visual Abstract
Can pushing K⁺ to the high-normal range reduce ICD shocks and hospitalizations? POTCAST challenges our fear of potassium.
Check out the VA by Jeyakumar Meyyappan and join the #NephJC conversation
TenPosts: pegcetacoplan in C3GN
Check out VALIANT recap: a 26-week analysis of the phase 3 trial of pegcetacoplan in C3GN! Thread by NephJC intern Bogdan Agavriloaei.
A ray of hope APPEARS for C3G
A VALIANT effort to combat complement disorders with pegcetacoplan
TenPosts LIBERATE-D
BigPAK or a bundle of balderdash?
Dialyze Less, Recover More? AKI’s Chance to Get LIBERATE-D
TenPosts PISCES
Check out PISCES recap: a whale of a tale of fish oil and cardio-protection in ESRD! Thread by NephJC intern Sai Vani
