Background
Cristina Adriana Popa
Is TRPC6 inhibition for FSGS a trick or a treat?

This week, we will discuss a phase 2 trial of the TRPC6 inhibitor BI 764198 in FSGS—an early signal for a podocyte-targeted therapy showing proteinuria reduction but set against small numbers, heterogeneity, and methodological trade-offs that frame this as direction-finding rather than definitive evidence.

Is TRPC6 inhibition for FSGS a trick or a treat?
Background
Cristina Adriana Popa
Why-dralazine?! Population risk of drug induced ...

This week, we will discuss why a large registry cohort was needed to move past decades of scattered case reports and clarify the true risk of hydralazine‑associated vasculitis. When rare events hide in noise, only scale can reveal the signal. Can population‑level data finally bring this paradox into focus?

Why-dralazine?! Population risk of drug induced vasculitis
Background
Cristina Adriana Popa
From missed opportunities to equitable access: ...

Summary of the STEPS trial which will be a twitter spaces discussion

From missed opportunities to equitable access: Can STEPS redesign the kidney transplant pathway?
Background
Cristina Adriana Popa
Searchin’ For My Lost Shaker of Salt- Targeted ...

This week, we will discuss the HIT trial- a large randomized study challenging one of the most reflexive responses in hospital medicine: see hyponatremia, fix the sodium. But what if correcting the number doesn’t change what actually matters?

Searchin’ For My Lost Shaker of Salt- Targeted Treatment of Hyponatremia
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swapnil hiremath
NephJC Covers LBCTs at the World Congress

The NephJC editors cover the simultaneous publication from the world congress

osmotic demyelination

Searchin’ For My Lost Shaker of Salt- Targeted Treatment of Hyponatremia

Searchin’ For My Lost Shaker of Salt- Targeted Treatment of Hyponatremia

This week, we will discuss the HIT trial- a large randomized study challenging one of the most reflexive responses in hospital medicine: see hyponatremia, fix the sodium. But what if correcting the number doesn’t change what actually matters?

Hiponatremia: El Resumen Visual

La hiponatremia es uno de los trastornos electrolíticos más frecuentes en pacientes hospitalizados y se asocia de manera consistente con peores desenlaces. Su corrección mejora los valores, pero ¿realmente mejora los desenlaces clínicos ?

Revisa el resumen visual por Brian Rifkin y el nuevo formato de #NephJC

The cause as a cure? The Case for a DDAVP clamp in severe Hyponatremia

The cause as a cure? The Case for a DDAVP clamp in severe Hyponatremia

This week, we will discuss an observational study - a very large series of using DDAVP for treatment of hyponatremia. Yes, you read that right. Read the paper for free thanks to Am J Med and join us on March 27/28 to discuss.