NephJC is a nephrology journal club that uses Twitter to discuss the research, guidelines, and editorials that are driving nephrology forward.
This week, during kidney month and NephMadness season, we will discuss the USRDS report as well as the ISN Global Kidney Health Atlas report from 2024.
This week on NephTrials we will discuss the PROTECT-V trial, a platform trial for preventing COVID-19 infections in the vulnerable kidney populations.
This week, we will discuss the SLEEP-HD trial, which examined if trazodone or CBT are better than placebo in helping people sleep.
This week, we will discuss the recently published KDIGO lupus guidelines. Published a couple of years after the big GN guidelines - let us dive in to see what’s new in lupus nephritis
This week, we will be discussing a randomized controlled trial of eculizumab in STEC-HUS. Will eculizumab manage to surpass its well-established reputation as expensivumab and demonstrate some positive results?
2023 brought us has dogma shredding data on hyponatremia and the importance of different diuretics. It has new therapies for old diseases like IgA and hypertension. New drugs for new diseases like inaxaplin for AMKD. And it has new data on old debates like what IVF is best and do thiazides really prevent kidney stones. It is a great list. Dig in!
This week we will discuss the article from Lancet on the addition of an ASI to background RASi and empagliflozin. Did this work?
This week, the last 2023’ NephJC resurfaces an old dilemma, in a different SPACE- non-cardiac surgery. Should we STOP ACEi, or do we know better?
This week, we will discuss yet another endothelin antagonist trial, on a background of flozins, in proteinuric CKD. Will flozins help breakthrough the endothelin badness?
This week, we will discuss sparsentan again, but this time in FSGS. This is the largest FSGS trial ever. Will endothelin antagonists crack the sclerotic FSGS segment?
This week on #NephTrials, we will discuss platform trials, anchoring the discussion to the BEAT-Calci trial, which has a number of interesting design features.
This week, nephrologists hope they found the key to no-dialysis-land, where kindness and detailed, multistep interventions make the path to kidney transplant much easier. This was foreseen in our Freely Filtered episode and disputed during #KidneyWK 2023 late-breaking clinical trials session. Still, when it comes to RCTs’ results, will it be Deja Vu or a happy ending?
This week, we will have a salty debate on what nephrologists love the most: hyponatremia and numbers. The main question: are guideline hyponatremia rates a waste of time?
This week on NephJC we are hashing out the Pragmatic Urinary Sodium-based treatment algoritHm in Acute Heart Failure (PUSH-AHF) trial!
This week, we will discuss some groundbreaking work on elucidating the adaptive and maladaptive cellular transcription and gene activation of the kidney in healthy and diseased states.
Classic scenario: young doctor, old patient with asymptomatic hypertension…
This week we are going against our instinct to normalize blood pressure numbers and listening to our wise elders.
What do you do when you suspect AIN (and eosinophils aren’t helpful) and you can’t get a kidney biopsy? CXCL9 is a newly discovered urinary marker that may help in the diagnosis of AIN. This week we will discuss the process of isolating and utilizing this new diagnostic test.
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This week, we put our best fluid forward to discuss whether balanced crystalloids reduce the incidence of DGF after deceased donor kidney transplant compared to normal saline.
In this edition of NephTrials, we will discuss the importance of PROS, PROMS, PREMS, anchoring the discussion to the SWIFT trial
This week, we will discuss CONVINCE, a randomized controlled trial, about the long-lasting battle between hemodialysis and hemodiafiltration. Will it convince the unconvinced, or will it diffuse even more uncertainty into community?
This week, we will discuss a systematic review challenging a common practice: the use of sodium thiosulfate in calciphylaxis.
This week, we will discuss the effects of oral bicarbonate therapy in kidney transplant recipients.
Preserve-Transplant Study from Lancet.
This week, we will discuss another IgA Nephropathy trial - Sparsentan this time. A dual endothelin antagonist and angiotensin receptor antagonist.
This week, we will discuss the resounding triumph of rituximab in maintenance therapy for ANCA-associated vasculitis. RIP Azathioprine?
This week, we will discuss Inaxaplin for APOL1 mediated kidney disease (AMKD). Taking the octopus by the horns.
This week, we will discuss the NOSTONE trial. Another renal reversal that will be practice changing. Should we stop using HCTZ for kidney stone prevention.
This week, we will discuss the MAIN trial of MMF monotherapy in IgA Nephropathy. Pairs nicely with the NephMadness IgA Region discussion!
This week, we will discuss whether pretransplant workup matters. This topic is also a bracket for NephMadness this year. Let’s dive in!
In this edition of NephTrials, we will discuss the bewildering world of master protocols, comprising of platform, umbrella and basket trials - with the example of the RENAL LIFECYCLE trial.
Upcoming Twitter chats
All scheduled chats are tentative. We may change the schedule depending on the whims of the NephJC work group
March 12 and 13: CKD Prevalence (we will discuss the 2023 USRDS report and touch upon the Lancet ISN-GKHA report)
March 26 and 27: Preeclampsia biomarker (Thadani et al, NEJM Evidence)
Twice a month (that’s aspirational, not a promise), the filtrate (Jennie Lin, Joel Topf, Jordy Cohen, Joshua Waitzman, Nayan Arora, Sophia Ambruso, and Swapnil Hiremath) sit down and recap the latest NephJC discussion. We go as deep as it takes. Give it a listen.
We measure blood pressure in the clinic and we treat hypertension. And we should.
We measure blood pressure in the hospital and we treat hypertension. But Should we?
Modern medical education doesn’t go to the comparative physiology well very often. So when we do, it is always fresh and exciting. Join the Filtrate as we explore the fascinating world of the Gila Monster and Mourning Dove.
So this one has been on the hard drive gathering dust for quite awhile. There were significant technical problems (in otherwords, Joel screwed up, but the episode is now complete and despite some obvious stutters, it turned out pretty good.
Introducing NephJC Collections
See the blog post describing this inititiative.
In the last year, NephJC has injected some statistical muscle into its editorial team (thank you Perry Wilson and Laurie Tomlinson). Then Manasi Bapat volunteered to create some cogent explainers for the various techniques that are routinely described in the methods section most of us skip over as we rush to the results. Here are the recent posts...
This week on NephTrials we will discuss the PROTECT-V trial, a platform trial for preventing COVID-19 infections in the vulnerable kidney populations.
This week on #NephTrials, we will discuss platform trials, anchoring the discussion to the BEAT-Calci trial, which has a number of interesting design features.
In this edition of NephTrials, we will discuss the importance of PROS, PROMS, PREMS, anchoring the discussion to the SWIFT trial
In this edition of NephTrials, we will discuss the bewildering world of master protocols, comprising of platform, umbrella and basket trials - with the example of the RENAL LIFECYCLE trial.
The next #Nephtrials discussion will feature a deep dive into convection/hemodiafiltration, and the ongoing registry based trial, H4RT
After cluster RCTs and pragmatic trials, we will discuss the role of run in periods and what we try to achieve by having them in clinical trials. Read on.
This week we discuss cluster RCTs. How do you conduct, consent, analyse and interpret these? Why do you do cluster RCTs? Let’s discuss using the Dial-Mag trial as an example.
Join us for the first edition of the #NephTrials chat. Let’s take a deep dive into pragmatic trials, and take a specific example - the Phosphate trial, to anchor the discussion.
NephTrials: where NephJC joins forces with ISN ACT and ISN Academy, to bring the social media expertise from the NephJC community and the methods expertise from ISN-ACT.
In this edition of #Nephstats, we look at Number Needed to Treat (NNT), a controversial topic creates ripples and roars on social media amongst stat savvy physicians, epidemiologists and biostatisticians. This seems like such a simple and easy number to make sense of a trial’s importance - what could be controversial or wrong about it?
2023 Perry Wilson How Medicine Works and When It Doesn't
2022 Walter Isaacson The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race
2021 Joshua D Mezrich When Death Becomes Life: Notes from a Transplant Surgeon
2020 Rana Awdish’s In Shock
2019 Andrew Bomback’s Doctor (Object Lessons)
2018 Siddhartha Mukherjee's Laws of Medicine, Field Notes from an Uncertain Science
2017 Vanessa Grubb's Hundreds of Interlaced Fingers.
2016 Eric Topol's The Patient Will See You Now
2015 Atul Gawande's Being Mortal
Steve Quinlan is a patient who did PD for a year. He looked at the 2020 ISPD guidelines of adequacy and he has thoughts…