Background
swapnil hiremath
Double Trouble: ddAVP and the Bleeding Biopsy

This week, we will discuss a double header: two single centre ddAVP trials in kidney biopsy from India.

Double Trouble: ddAVP and the Bleeding Biopsy
Background
Cristina Adriana Popa
Kidney Allografts-Play With Fire, Get Burned

This week, we will discuss the prognostic role of microvascular inflammation in kidney transplantation. Can the capillaries whisper their damage in lesions before antibodies speak? Maybe this study compels us to treat the injury we see, not just the disease we can name…

Kidney Allografts-Play With Fire, Get Burned
Background
swapnil hiremath
Metformin- Should I Stay or Should I Go

This week, we will discuss another target trial emulation study. The FDA says to stop metformin at a GFR of 30. Are they right?

Metformin- Should I Stay or Should I Go
Background
Brian Rifkin
KDIGO 2025 ADPKD Guidelines Review

This week, we will discuss the first iteration of KDIGO’s 2025 guidelines on ADPKD.  These guidelines are a result of a decade of global collaboration between physicians, researchers, advocates, and patients. The guidelines incorporate ADPKD-specific care as well as many general CKD management practice points.


KDIGO 2025 ADPKD Guidelines Review
Background
Cristina Adriana Popa
REGENCY: A B-Cell Super Destroyer in Lupus

This week, we will celebrate in advance World Kidney Day by discussing the results of OBInutuzumab in active lupus nephritis. The LUNAR trial (rituximab versus placebo) was “almost” positive, but not quite there. Would Obi overpower its cousin ritux? ✨

REGENCY: A B-Cell Super Destroyer in Lupus

tweetorial

SLEEP-HD: is trazodone better in insomnia than CBT?

This trial rebranded trazodone as “trazodont” in dialysis population

Here We KDIGO Again: Lupus Nephritis 2024

New KDIGO guidelines since 2021, Lupus Nephritis is seeing lots of new therapeutics in the pipeline.

Salt in the wounds?

Fascinating observational study on hyponatraemia correction rates this week, catch-up here.

Natriuresis (UNa) measurements to guide diuretic strategies?

TenTweetNephJC on X. Natriuresis guidance for intensification of diuretics is one strategy to PUSH decongestion in patient’s with acute heart failure.

Precision medicine in AIN?

TenTweetNephJC on AIN = TenXNephJC on AIN = XXNephJC on AIN…? Twitter not being called twitter is confusing.

Fluid Wars: Plasmalyte Strikes Back

Patients are given a lot of fluid post-transplant, but which to choose? Catch up on the latest evidence here.

TenXeetNephJC? TenPostNephJC? It's HDF and CONVINCE anyway.

Huge trial on our core work, catch-up here

#TenTweetsNephJC does STS and CUA

WIth no RCTs to go on, we review a meta-analysis on sodium thiosulphate for calciphylaxis

Giving oral bicarb raises serum bicarb

RCT of PO sodium bicarbonate in patients with renal transplant to see if impacts stability of renal function - catch up here!

RITAZAREM - how to manage relapse in AAV

Was anyone really backing azathioprine against vitamin R in relapsed ANCA-associated vasculitis? Catch-up on the RCT here.

Be excited, no need to APOLogize

Huge news in APOL1 nephropathy - ten tweets to fill you in here:

Gathering no moss

Thiazides to prevent rolling stones - the Ten Tweet summary of NOSTONE is here.