Can we move beyond slowing CKD to actually repairing the kidney? Here is the summary of the last #NephJC chat discussing Rilparencel, a renal autologous cell therapy (REACT) infusion, and its effect on eGFR slope.
Thread by Akshaya Jayachandran
Is REACT (Renal Autologous Cell Therapy) the “fifth pillar” in diabetic kidney disease?
To INFINITI and Beyond: SGLT2 Inhibitors in Kidney Transplant Patients
VALIANT: El Resumen Visual
El ensayo clínico aleatorizado fase 3 VALIANT demostró que la inhibición proximal de C3 con pegcetacoplan logra una reducción significativamente mayor de la proteinuria en comparación con placebo en pacientes con glomerulopatía C3 (C3G) y glomerulonefritis membranoproliferativa primaria mediada por complejos inmunes (IC-MPGN). Este estudio se basa en estrategias previas de inhibición proximal del complemento y refuerza el papel de las terapias dirigidas a la fisiopatología en la C3G.
No te pierdas el resumen visual creado por Dra. Akshaya Jayachandran y súmate a la discusión en #NephJC por Bluesky 🦋
VALIANT: The Visual Abstract
The VALIANT phase 3 RCT shows that proximal C3 inhibition with pegcetacoplan leads to a significantly greater reduction in proteinuria compared with placebo in patients with C3G and primary immune-complex MPGN. This trial builds on prior upstream complement strategies and strengthens the case for disease-targeted therapy in C3G.
Check out the VA Dr. Akshaya Jayachandran and don´t forget to join #NephJC on bluesky.
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Fish Oil in Dialysis: A Big Catch or an Empty Net
Kidney transplant diaries: achieving immune tolerance by chimerism
A thread on the most relevant part of the chat on tolerance induction in HLA-matched transplant with donor hematopoietic stem cells (MDR-101). Thread by Akshaya Jayachandran.
Chimerism and Immune Tolerance: Can We Says Goodbye to Immunosuppression?
ACHIEVE: el resumen visual
¿La espironolactona será la heroína que conquiste el corazón en hemodiálisis?
Descúbrelo en la travesía del ensayo ACHIEVE y únete a la discusión en #NephJC.
The ACHIEVE visual abstract
Does spironolactone decrease cardiovascular disease and heart failure hospitalizations in patients on dialysis?
Check out this crisp VA by Dr Akshaya Jayachandran.
#NephJC Summer Book Club Everything Is Tuberculosis poetry
Las Perspectivas del estudio CRIC: el Resumen Visual
Basado en los datos del estudio CRIC, este análisis profundiza en si esa discordancia (TFGe dif) es solo “ruido”… o una señal clínica que hemos estado ignorando.
Echale un vistazo al resumen visual realizado por el equipo de internos de #NephJC Dr Sai Vani Yellampalli y Akshaya Jayachandran
Insights from the CRIC Study: Visual Abstract
Based on data from the CRIC study, this analysis dives deep into whether this lab mismatch is just noise… or a clinical signal we’ve been missing.
Check out the beautiful visual abstract made by our NephJC interns Sai Vani Yellampalli and Akshaya Jayachandran. Great team work!!!
