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NephJC 2026 Fall Pledge Drive

Help keep NephJC a vital, original, and unbiased source of medical education.

NephJC 2026 Fall Pledge Drive
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Brian Rifkin
REFINe-ing AI’s Role in Nephrology Diagnosis

This week, we will discuss the use of LLMs for the diagnosis of complex nephrology cases. Can AI help nephrologists nail the correct diagnosis?

REFINe-ing AI’s Role in Nephrology Diagnosis
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Akshaya J
Too sweet to be true? Prophylactic SGLT2 ...

MERCURI-2 reports that dapagliflozin cuts postoperative AKI after cardiac surgery, but the headline result is mostly a urine-output story, not a creatinine one. That matters: urine output after surgery is easily swayed by anesthesia, fluid shifts, vasopressors, and a diuretic drug in the mix. Until dapagliflozin shows it protects kidney function, not just urine output.

Too sweet to be true? Prophylactic SGLT2 inhibitors before cardiac surgery
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Cristina Adriana Popa
Buffering without benefit? The SODa-BIC study

This week, we will discuss SODaBIC trial: with ICU acidosis driven by multiple overlapping mechanisms, is bicarbonate infusion supported by robust evidence, or does it persist mainly out of habit rather than physiology?

Buffering without benefit? The SODa-BIC study
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Pallavi Prasad
Beyond Diabetic Kidney Disease: FIND-ing ...

FIND-CKD extends finerenone beyond diabetic kidney disease, showing slower eGFR decline and sustained albuminuria reduction in non-diabetic CKD. While the benefits are modest and cardiovascular effects remain uncertain, the trial opens the door to broader use of nsMRAs and raises important questions about combination therapy with SGLT2 inhibitors.

Beyond Diabetic Kidney Disease: FIND-ing Finerenone's Next Role

finerenone

FIND-CKD trial on Instagram

FIND-CKD on Instagram

A more visual summary of the trial and relevant context (just 6 images to look at!). Infographics by Andreea Manolea

Bonus: more on finerenone in proteinuric CKD universe- visuals by Cristina Popa

FIND CKD: The Visual Abstract

Is finerenone ready to move beyond diabetes?

The FIND-CKD phase 3 arrived from the #ERA26 and is the first one to show kidney protection with finerenone in non-diabetic CKD.

The next challenge is no longer whether finerenone belongs in non-diabetic CKD, but how to best combine with the rest of the pillars to maximize protection.

Check out the newest VA created by our intern Raquel Barba

FIND CKD: El Resumen Visual

¿Está la finerenona lista para ir más allá de la diabetes?

El estudio FIND-CKD recien llegado del #ERA26, es el primer ensayo fase 3 que demuestra protección renal con finerenona en pacientes con ERC no diabética.

El siguiente reto ya no es si la finerenona tiene un lugar en la ERC no diabética, sino cómo combinarla de la mejor manera con el resto de los pilares del tratamiento para maximizar la protección renal.

No se pierdan el nuevo Visual Abstract creado por nuestra interna Raquel Barba

Análisis del Estudio FINE-HEART_El Resumen Visual

El análisis FINE-HEART llega a NephJC, donde se agrupan tres ensayos clínicos clave que evalúan el impacto de la finerenona en pacientes con insuficiencia cardíaca y enfermedad renal diabética.

¿Será la finerenona la próxima terapia de impacto para mejorar el eje cardio-reno-metabólico?

Descubre más en este resumen visual creado por la estudiante del NSMC, @KajareeG

Re”FINE”ing the role of non steroidal MRAs in Cardio Kidney Metabolic syndrome

Re”FINE”ing the role of non steroidal MRAs in Cardio Kidney Metabolic syndrome

This week, we will discuss non-steroidal mineralocorticoid antagonist in the multiverse of cardiovascular-kidney-metabolic. What FINEHEART pooled analysis would add to what we already learned from FIDELIO-DKD trial?