This week, we will discuss the fresh-off-the-press trials from this week’s issue of the NEJM: PERL and CKD-FiX. These two trials examined if the uric acid and CKD link is causal: by measuring CKD progression after giving patients allopurinol. Be ready for another medical reversal.
The PERL study visual abstract
Anju Yadav did a great job on the visual abstract for PERL.
The CKD-Fix visual abstract
Arun Rajasekaran did a great job. I can’t believe it is his first visual abstract.
Diagnosing Aldosteronism Visual Abstract
Samira Farouk did a great job with this week’s Visual Abstract
Diagnosing Aldosteronism
Empagliflozen is a diuretic? What? The Visual Abstract
Anju Yadav put together a stunning visual abstract for this week’s NephJC. Take a look.
DAPA-HF, the Visual Abstract
OIn order to understand the significance of this week’s NephJC you should have more than a passing familiarity with DAPA-HF one of the foundational SGLT2i studies. To help you brush up here is a superior visual abstract by Sudha Mannemuddhu
SGLT2 inhibitors: Sweet (and Salty) Pee
No Pain for the Kidneys from NSAIDs
NSAID vs Opioid in CKD, the Visual Abstract
Ali Mehdi comes up big for this week’s NephJC.
Ischemia CKD: The Visual Abstract
Beautiful work from NSMC intern, Krishna Agarwal
The NEJM also did make a nice VA, in their own style
Renalism Returns
COVID in the Kidney: An Autopsy Series
MinTac: The Visual Abstract
The trial is from cJASN, so we do have a visual abstract from Pablo Garcia, in the cJASN style
And Omar as well created another visual abstract, in his own inimitable style
Minimal Role for Steroids in Minimal Change Disease?
TRANSPLANT
This page discusses the common questions transplant professionals as well as transplant patients may have with COVID-19. We have few facts and little evidence, and those are laid out below. Locally, the decisions being taken depend on local resources, logistics and other factors, and hence local practice may appropriately vary.
PEDIATRICS
COVID-19, the disease caused by SARS-CoV-2, has rapidly become a global pandemic. This review aims to complement the other NephJC pages with a focus on how children with kidney disease are impacted by this pandemic. Our aim is to review what we know about COVID-19 as it pertains to kidney disease in kids.
DIALYSIS and CKD
Byrd's Words: Preprints and Peer Review
ACUTE KIDNEY INJURY
As with all the other pages on COVID-19 here on NephJC, this page on AKI & the discussion are not meant to be treatment recommendations based on sound evidence. Our aim on this page is to merely discuss the science of what we know, and some of the biology and mechanisms as well as practical management aspects.












