swapnil hiremath

September 17, 2023

Background

The Kidney Cellular Architecture: A Renal Research Roadmap

swapnil hiremath

September 17, 2023

Background

The Kidney Cellular Architecture: A Renal Research Roadmap

This week, we will discuss some groundbreaking work on elucidating the adaptive and maladaptive cellular transcription and gene activation of the kidney in healthy and diseased states.

Cristina Adriana Popa

September 5, 2023

Background

Pressure! Pushing down on me, pushing down on you: Should we be aggressively treating inpatient hypertension?

Cristina Adriana Popa

September 5, 2023

Background

Pressure! Pushing down on me, pushing down on you: Should we be aggressively treating inpatient hypertension?

Classic scenario: young doctor, old patient with asymptomatic hypertension…
This week we are going against our instinct to normalize blood pressure numbers and listening to our wise elders.

Jade Teakell

August 21, 2023

Background

CXCL9: A Urinary Marker ExplAINed

Jade Teakell

August 21, 2023

Background

What do you do when you suspect AIN (and eosinophils aren’t helpful) and you can’t get a kidney biopsy? CXCL9 is a newly discovered urinary marker that may help in the diagnosis of AIN. This week we will discuss the process of isolating and utilizing this new diagnostic test.

Guest User

July 25, 2023

Background

Art of Balance In Preventing Delayed Graft Function - BEST FLUIDS for better outcomes

Guest User

July 25, 2023

Background

Art of Balance In Preventing Delayed Graft Function - BEST FLUIDS for better outcomes

This week, we put our best fluid forward to discuss whether balanced crystalloids reduce the incidence of DGF after deceased donor kidney transplant compared to normal saline.

swapnil hiremath

July 12, 2023

Background

Breaking the discord between patients’ goals and traditional trial outcomes: the SWIFT trial

swapnil hiremath

July 12, 2023

Background

Breaking the discord between patients’ goals and traditional trial outcomes: the SWIFT trial

In this edition of NephTrials, we will discuss the importance of PROS, PROMS, PREMS, anchoring the discussion to the SWIFT trial

Cristina Adriana Popa

July 11, 2023

Background

HDF vs HD: Need for CONVINCE-ing Evidence

Cristina Adriana Popa

July 11, 2023

Background

HDF vs HD: Need for CONVINCE-ing Evidence

This week, we will discuss CONVINCE, a randomized controlled trial, about the long-lasting battle between hemodialysis and hemodiafiltration. Will it convince the unconvinced, or will it diffuse even more uncertainty into community?

swapnil hiremath

June 19, 2023

Background

Sodium Thiosulphate: An Elixir Vitae against the Sorcery of Calcific Uremic Arteriolopathy?

swapnil hiremath

June 19, 2023

Background

Sodium Thiosulphate: An Elixir Vitae against the Sorcery of Calcific Uremic Arteriolopathy?

This week, we will discuss a systematic review challenging a common practice: the use of sodium thiosulfate in calciphylaxis.

joel topf

June 11, 2023

Meta, Background

Summer Book Club 2023. How Medicine Works and When It Doesn't by F. Perry Wilson

joel topf

June 11, 2023

Meta, Background

Summer Book Club 2023. How Medicine Works and When It Doesn't by F. Perry Wilson

The NephJC Summer Book Club returns! Start reading F. Perry Wilson’s How Medicine Works and When It Doesn't so you can join us August 8th and 9th for book club!

Jade Teakell

June 5, 2023

Background

A litmus test: Does Sodium Bicarbonate Prevent Graft Function Decline?

Jade Teakell

June 5, 2023

Background

A litmus test: Does Sodium Bicarbonate Prevent Graft Function Decline?

This week, we will discuss the effects of oral bicarbonate therapy in kidney transplant recipients.
Preserve-Transplant Study from Lancet.

swapnil hiremath

May 23, 2023

Background

SPARE a Thought for SPARSENTAN?

swapnil hiremath

May 23, 2023

Background

This week, we will discuss another IgA Nephropathy trial - Sparsentan this time. A dual endothelin antagonist and angiotensin receptor antagonist.

swapnil hiremath

May 9, 2023

Background

Rituximab, Remission, and Relapses in ANCA Vasculitis

swapnil hiremath

May 9, 2023

Background

Rituximab, Remission, and Relapses in ANCA Vasculitis

This week, we will discuss the resounding triumph of rituximab in maintenance therapy for ANCA-associated vasculitis. RIP Azathioprine?

joel topf

April 25, 2023

Background

Inaxaplin and proteinuric kidney disease treatment:Taking the octopus by its horns

joel topf

April 25, 2023

Background

Inaxaplin and proteinuric kidney disease treatment:Taking the octopus by its horns

This week, we will discuss Inaxaplin for APOL1 mediated kidney disease (AMKD). Taking the octopus by the horns.

swapnil hiremath

April 11, 2023

Background

Leaving No Stones Unturned: HCTZ in Nephrolithiasis

swapnil hiremath

April 11, 2023

Background

Leaving No Stones Unturned: HCTZ in Nephrolithiasis

This week, we will discuss the NOSTONE trial. Another renal reversal that will be practice changing. Should we stop using HCTZ for kidney stone prevention.

swapnil hiremath

March 28, 2023

Background

MMF in IgA: Inching into the MAINstream?

swapnil hiremath

March 28, 2023

Background

MMF in IgA: Inching into the MAINstream?

This week, we will discuss the MAIN trial of MMF monotherapy in IgA Nephropathy. Pairs nicely with the NephMadness IgA Region discussion!

swapnil hiremath

March 14, 2023

Background

Behind the Screen: Cardiac testing before Kidney Transplantation

swapnil hiremath

March 14, 2023

Background

Behind the Screen: Cardiac testing before Kidney Transplantation

This week, we will discuss whether pretransplant workup matters. This topic is also a bracket for NephMadness this year. Let’s dive in!

swapnil hiremath

March 4, 2023

Background

Master Drugs Meet The Master Protocol: The Renal Lifecycle Trial

swapnil hiremath

March 4, 2023

Background

Master Drugs Meet The Master Protocol: The Renal Lifecycle Trial

In this edition of NephTrials, we will discuss the bewildering world of master protocols, comprising of platform, umbrella and basket trials - with the example of the RENAL LIFECYCLE trial.

Jade Teakell

February 28, 2023

Background

Vacillation in Atrial Fibrillation on Hemodialysis Continues

Jade Teakell

February 28, 2023

Background

Vacillation in Atrial Fibrillation on Hemodialysis Continues

This week, we will discuss the a small step forward in understanding the role of anticoagulation in atrial fibrillation in ESRD.

Guest User

February 21, 2023

Background

Ask ASN: A special NephJC

Guest User

February 21, 2023

Background

AskASN is back with a discussion about medical director responsibilities - from the ASN: Excellent Patient Care workgroup

Guest User

February 7, 2023

Background

TRANSFORM-HF: Solving the Diuretic Mystery with a Twist of Vintage vs Modern

Guest User

February 7, 2023

Background

TRANSFORM-HF: Solving the Diuretic Mystery with a Twist of Vintage vs Modern

TRANSFORM-HF was long awaited - hoping to transform the furosemide users to torsemide. Did this gambit work or looped back on itself?

swapnil hiremath

February 7, 2023

Background

The Distal Convoluted Tubule Showdown: Chlorthalidone versus HCTZ

swapnil hiremath

February 7, 2023

Background

The Distal Convoluted Tubule Showdown: Chlorthalidone versus HCTZ

We love switching from HCTZ or bendroflumethiazide to chlorthalidone or indapamide. We are so smart and smug when we do this. Are we right?