Does spironolactone decrease cardiovascular disease and heart failure hospitalizations in patients on dialysis?
Check out this crisp VA by Dr Akshaya Jayachandran.
This week, we will discuss SODaBIC trial: with ICU acidosis driven by multiple overlapping mechanisms, is bicarbonate infusion supported by robust evidence, or does it persist mainly out of habit rather than physiology?
FIND-CKD extends finerenone beyond diabetic kidney disease, showing slower eGFR decline and sustained albuminuria reduction in non-diabetic CKD. While the benefits are modest and cardiovascular effects remain uncertain, the trial opens the door to broader use of nsMRAs and raises important questions about combination therapy with SGLT2 inhibitors.
Can rivaroxaban improve cardiovascular outcomes in patients with advanced CKD.? Although vascular inflammation and thrombosis are at the heart of CV damage, anticoagulants have not previously shown benefits in CVD patients.
This week, NephJC will discuss whether obinutuzumab is ready to outperform tacrolimus in primary membranous nephropathy
Does spironolactone decrease cardiovascular disease and heart failure hospitalizations in patients on dialysis?
Check out this crisp VA by Dr Akshaya Jayachandran.
The summer book club started in 2015, with one of the best books we have done in book club, Atul Gawande's Being Mortal. I think it should be required reading for all physicians. So now, in 2025, it is the NephJC Summer Book’s tenth anniversary (which represents our eleventh book). The history has been rich:
Aunque sabemos que el fósforo elevado se asocia consistentemente con mayor mortalidad y eventos cardiovasculares, aún no existe evidencia definitiva de que bajarlo de forma agresiva cambie el pronóstico.
Revisemos el resumen visual del estudio HiLo, creado Sejal Lakhani que evaluó objetivos altos vs. bajos de fósforo sérico en pacientes en hemodiálisis.
Is a lower versus higher phosphate target beneficial to patients undergoing hemodialysis?
Check out this crisp VA by Dr Sejal Lakhani
Check out the summary on eGFR diference chat, done by NephJC intern Bogdan Agavriloaei
Basado en los datos del estudio CRIC, este análisis profundiza en si esa discordancia (TFGe dif) es solo “ruido”… o una señal clínica que hemos estado ignorando.
Echale un vistazo al resumen visual realizado por el equipo de internos de #NephJC Dr Sai Vani Yellampalli y Akshaya Jayachandran
Based on data from the CRIC study, this analysis dives deep into whether this lab mismatch is just noise… or a clinical signal we’ve been missing.
Check out the beautiful visual abstract made by our NephJC interns Sai Vani Yellampalli and Akshaya Jayachandran. Great team work!!!
Check out CONFIDENCE recap
Check out the beautiful visual abstract made by NephJC intern Michelle Fravel.
El ensayo CONFIDENCE evaluó la combinación de finerenona + empagliflozina en ERC + DM2: mayor reducción de CACu a 180 días. ¿Estamos listos para iniciar la terapia combinada desde el principio?
Revisa el resumen visual por Michelle Fravel
In just over a decade of critical appraisal on NephJC, we have done several experiments. Some of them have worked out phenomenally well, such as the Freely Filtered podcast. Others were not ready for the time, such as the Google Hangouts. We want to try another such experiment, and hope we receive feedback to decide if this is something worthwhile that we should continue doing.
There are many studies and many trials and many reviews, and many guidelines that are published in Nephrology every week. Indeed, it is a golden era for randomized controlled trials in Nephrology. On the other hand, NephJC only occurs twice a month. It does take a lot of work, with the detailed critical appraisal, readable summary, visual, abstracts, and the chats. Sometimes the occasional, irregularly irregular podcast. Hence, we cannot deal with all the worthwhile studies that are coming out.
Enter NephJC Shorts.
This week, we are publishing a few short blogs. The purpose here is to cover some notable studies in brief. They do not receive the full, long, NephJC treatment. The articles we choose are those that the NephJC editorial team fancies, but suggestions are welcome. Since these are a shorter format, we don’t do a deep dive into the methods and don’t have a long list of the limitations and strengths. Think of them as a pithy version of the usual NephJC blog. Feedback welcome!
Iptacopan decreases proteinuria, now we get the 24-month eGFR data in patients with IgA Nephropathy.
Does Dual BAFF/APRIL Blockade with Telitacicept Reduce Proteinuria in Persistent Proteinuric IgA Nephropathy?
The NephJC Editors